ENSG00000103653


Homo sapiens

Features
Gene ID: ENSG00000103653
  
Biological name :CSK
  
Synonyms : CSK / C-terminal Src kinase / P41240
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.1
Gene start: 74782057
Gene end: 74803198
  
Corresponding Affymetrix probe sets: 202329_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457497
Ensembl peptide - ENSP00000454906
Ensembl peptide - ENSP00000457714
Ensembl peptide - ENSP00000220003
Ensembl peptide - ENSP00000414764
Ensembl peptide - ENSP00000454640
NCBI entrez gene - 1445     See in Manteia.
OMIM - 124095
RefSeq - XM_017021925
RefSeq - NM_001127190
RefSeq - NM_001354988
RefSeq - NM_004383
RefSeq - XM_005254165
RefSeq Peptide - NP_001341917
RefSeq Peptide - NP_001120662
RefSeq Peptide - NP_004374
swissprot - H3BU69
swissprot - H3BUM9
swissprot - H3BN15
swissprot - B2R6Q4
swissprot - P41240
Ensembl - ENSG00000103653
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cskENSDARG00000067996Danio rerio
 CSKENSGALG00000031270Gallus gallus
 CskENSMUSG00000032312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726452
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332240
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700740
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560537
TXK / P42681 / TXK tyrosine kinaseENSG0000007496636
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067135
FER / P16591 / FER tyrosine kinaseENSG0000015142234
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201034
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251134
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326333


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035026  Tyrosine-protein kinase CSK
 IPR035027  CSK-like, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IBA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0034332 adherens junction organization IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042997 negative regulation of Golgi to plasma membrane protein transport IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway IBA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding TAS
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains
Integrin alphaIIb beta3 signaling
PD-1 signaling
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000035403 VCL / P18206 / vinculin  / complex
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / reaction / complex
 ENSG00000076641 PAG1 / Q9NWQ8 / phosphoprotein membrane anchor with glycosphingolipid microdomains 1  / complex / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction / complex
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / reaction / complex
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / reaction / complex
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction / complex
 ENSG00000089159 PXN / P49023 / paxillin  / complex
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000197646 Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000188389 PDCD1 / Q15116 / programmed cell death 1  / reaction / complex
 ENSG00000120217 CD274 / Q9NZQ7 / CD274 molecule  / reaction / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000134242 PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22  / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex






 

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