ENSG00000120217


Homo sapiens

Features
Gene ID: ENSG00000120217
  
Biological name :CD274
  
Synonyms : CD274 / CD274 molecule / Q9NZQ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.1
Gene start: 5450503
Gene end: 5470566
  
Corresponding Affymetrix probe sets: 223834_at (Human Genome U133 Plus 2.0 Array)   227458_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370985
Ensembl peptide - ENSP00000370989
NCBI entrez gene - 29126     See in Manteia.
OMIM - 605402
RefSeq - NM_001267706
RefSeq - NM_014143
RefSeq Peptide - NP_001254635
RefSeq Peptide - NP_054862
swissprot - Q9NZQ7
Ensembl - ENSG00000120217
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-241b2.5ENSDARG00000100899Danio rerio
 CD274ENSGALG00000015032Gallus gallus
 Cd274ENSMUSG00000016496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2ENSG0000019764632


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032693 negative regulation of interleukin-10 production IMP
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0042102 positive regulation of T cell proliferation TAS
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production IMP
 biological_processGO:1905404 positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process IDA
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000188389 PDCD1 / Q15116 / programmed cell death 1  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr