Manteia

ENSG00000111679

Homo sapiens

Features

Gene ID:	ENSG00000111679

Biological name :	PTPN6

Synonyms :	P29350 / protein tyrosine phosphatase, non-receptor type 6 / PTPN6

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	12
Strand:	1
Band:	p13.31
Gene start:	6946468
Gene end:	6961316

Corresponding Affymetrix probe sets:	206687_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000476175 Ensembl peptide - ENSP00000445646 Ensembl peptide - ENSP00000446345 Ensembl peptide - ENSP00000326010 Ensembl peptide - ENSP00000382376 Ensembl peptide - ENSP00000391592 Ensembl peptide - ENSP00000438740 Ensembl peptide - ENSP00000440114 Ensembl peptide - ENSP00000441044 Ensembl peptide - ENSP00000443393 Ensembl peptide - ENSP00000444805 NCBI entrez gene - 5777 See in Manteia. OMIM - 176883 RefSeq - XM_011520988 RefSeq - NM_002831 RefSeq - NM_080548 RefSeq - NM_080549 RefSeq - XM_006718994 RefSeq Peptide - NP_536859 RefSeq Peptide - NP_002822 RefSeq Peptide - NP_536858 swissprot - U3KQS1 swissprot - F5GXD4 swissprot - P29350 swissprot - F5GY79 swissprot - F5H0N8 swissprot - F5H1V7 swissprot - F5H4Z1 swissprot - F5H1Z8 swissprot - F5H5H9 swissprot - Q53XS4 Ensembl - ENSG00000111679

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ptpn6	ENSDARG00000089043	Danio rerio
PTPN6	ENSGALG00000014561	Gallus gallus
Ptpn6	ENSMUSG00000004266	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	ENSG00000179295	52
PTPRN / Q16849 / protein tyrosine phosphatase, receptor type N	ENSG00000054356	22
PTPRN2 / Q92932 / protein tyrosine phosphatase, receptor type N2	ENSG00000155093	21
PTPN5 / P54829 / protein tyrosine phosphatase, non-receptor type 5	ENSG00000110786	20
PTPRR / Q15256 / protein tyrosine phosphatase, receptor type R	ENSG00000153233	19
PTPN7 / P35236 / protein tyrosine phosphatase, non-receptor type 7	ENSG00000143851	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000242	PTP type protein phosphatase
IPR000387	Tyrosine specific protein phosphatases domain
IPR000980	SH2 domain
IPR003595	Protein-tyrosine phosphatase, catalytic
IPR012152	Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR016130	Protein-tyrosine phosphatase, active site
IPR029021	Protein-tyrosine phosphatase-like
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002244	hematopoietic progenitor cell differentiation	IEA
biological_process	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	IEA
biological_process	GO:0006470	protein dephosphorylation	IDA
biological_process	GO:0006915	apoptotic process	TAS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0008283	cell proliferation	IDA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0008285	negative regulation of cell proliferation	NAS
biological_process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0030154	cell differentiation	IDA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030220	platelet formation	IEA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0033277	abortive mitotic cell cycle	IEA
biological_process	GO:0033630	positive regulation of cell adhesion mediated by integrin	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IMP
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0035855	megakaryocyte development	IEA
biological_process	GO:0042130	negative regulation of T cell proliferation	IEA
biological_process	GO:0042267	natural killer cell mediated cytotoxicity	IEA
biological_process	GO:0043312	neutrophil degranulation	TAS
biological_process	GO:0043407	negative regulation of MAP kinase activity	IEA
biological_process	GO:0043409	negative regulation of MAPK cascade	IEA
biological_process	GO:0045577	regulation of B cell differentiation	IEA
biological_process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0050853	B cell receptor signaling pathway	IEA
biological_process	GO:0050859	negative regulation of B cell receptor signaling pathway	IEA
biological_process	GO:0050860	negative regulation of T cell receptor signaling pathway	IEA
biological_process	GO:0050900	leukocyte migration	TAS
biological_process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IEA
biological_process	GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS
biological_process	GO:0070372	regulation of ERK1 and ERK2 cascade	IDA
biological_process	GO:0070527	platelet aggregation	IEA
biological_process	GO:0071345	cellular response to cytokine stimulus	TAS
biological_process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	IMP
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005730	nucleolus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005911	cell-cell junction	IEA
cellular_component	GO:0016020	membrane	TAS
cellular_component	GO:0032991	protein-containing complex	IMP
cellular_component	GO:0035580	specific granule lumen	TAS
cellular_component	GO:0042105	alpha-beta T cell receptor complex	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:1904724	tertiary granule lumen	TAS
molecular_function	GO:0001784	phosphotyrosine residue binding	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	TAS
molecular_function	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IEA
molecular_function	GO:0017124	SH3 domain binding	IEA
molecular_function	GO:0019901	protein kinase binding	IPI
molecular_function	GO:0042169	SH2 domain binding	IEA
molecular_function	GO:0050839	cell adhesion molecule binding	IEA
molecular_function	GO:0140031	phosphorylation-dependent protein binding	IPI

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Regulation of KIT signaling

PECAM1 interactions

Costimulation by the CD28 family

PD-1 signaling

Signal regulatory protein family interactions

Platelet sensitization by LDL

Interleukin-3, Interleukin-5 and GM-CSF signaling

CD22 mediated BCR regulation

Neutrophil degranulation

Interferon gamma signaling

Regulation of IFNG signaling

Interleukin-37 signaling

Interferon alpha/beta signaling

Interleukin receptor SHC signaling

Regulation of IFNA signaling

Growth hormone receptor signaling

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000113525	IL5 / P05113 / interleukin 5	/ complex / reaction
ENSG00000091181	IL5RA / Q01344 / interleukin 5 receptor subunit alpha	/ complex / reaction
ENSG00000100368	CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit	/ complex / reaction
ENSG00000164399	IL3 / P08700 / interleukin 3	/ complex / reaction
ENSG00000164400	CSF2 / P04141 / colony stimulating factor 2	/ complex / reaction
ENSG00000185291	IL3RA / P26951 / interleukin 3 receptor subunit alpha	/ complex / reaction
ENSG00000027697	IFNGR1 / P15260 / interferon gamma receptor 1	/ reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ reaction
ENSG00000231389	P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	/ reaction
ENSG00000103653	CSK / P41240 / C-terminal Src kinase	/ reaction / complex
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ reaction / complex
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000007312	CD79B / P40259 / CD79b molecule	/ reaction / complex
ENSG00000197646	Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2	/ complex / reaction
ENSG00000049130	KITLG / P21583 / KIT ligand	/ reaction / complex
ENSG00000157404	KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase	/ complex / reaction
ENSG00000237541	P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	/ reaction
ENSG00000259384	GH1 / P01241 / growth hormone 1	/ reaction / complex
ENSG00000159110	IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2	/ reaction
ENSG00000167286	CD3D / P04234 / CD3d molecule	/ reaction
ENSG00000111679	PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6	/ complex
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ reaction / complex
ENSG00000170581	STAT2 / P52630 / signal transducer and activator of transcription 2	/ reaction
ENSG00000196735	P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	/ reaction
ENSG00000204287	P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha	/ reaction
ENSG00000112964	GHR / P10912 / growth hormone receptor	/ reaction / complex
ENSG00000111537	IFNG / P01579 / interferon gamma	/ reaction
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ reaction
ENSG00000211799	TRAV19 / T cell receptor alpha variable 19	/ reaction
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ reaction
ENSG00000211898	IGHD / P01880 / immunoglobulin heavy constant delta	/ reaction / complex
ENSG00000171855	IFNB1 / P01574 / interferon beta 1	/ reaction
ENSG00000198223	CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit	/ reaction / complex
ENSG00000211899	IGHM / P01871 / immunoglobulin heavy constant mu	/ reaction / complex
ENSG00000198851	CD3E / P07766 / CD3e molecule	/ reaction
ENSG00000012124	CD22 / P20273 / CD22 molecule	/ reaction / complex
ENSG00000159128	IFNGR2 / P38484 / interferon gamma receptor 2	/ reaction
ENSG00000136487	GH2 / P01242 / growth hormone 2	/ complex / reaction
ENSG00000105369	CD79A / P11912 / CD79a molecule	/ complex / reaction
ENSG00000157873	Q92956 / TNFRSF14 / TNF receptor superfamily member 14	/ reaction / complex
ENSG00000186265	BTLA / Q7Z6A9 / B and T lymphocyte associated	/ complex / reaction
ENSG00000142166	IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1	/ reaction
ENSG00000010610	CD4 / P01730 / CD4 molecule	/ reaction
ENSG00000120217	CD274 / Q9NZQ7 / CD274 molecule	/ complex / reaction
ENSG00000188389	PDCD1 / Q15116 / programmed cell death 1	/ complex / reaction
ENSG00000105397	TYK2 / P29597 / tyrosine kinase 2	/ reaction
ENSG00000196776	CD47 / Q08722 / CD47 molecule	/ complex / reaction
ENSG00000198053	SIRPA / P78324 / signal regulatory protein alpha	/ complex / reaction
ENSG00000204420	MPIG6B / O95866 / megakaryocyte and platelet inhibitory receptor G6b	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr