ENSG00000211899


Homo sapiens

Features
Gene ID: ENSG00000211899
  
Biological name :IGHM
  
Synonyms : IGHM / immunoglobulin heavy constant mu / P01871
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105851708
Gene end: 105856218
  
Corresponding Affymetrix probe sets: 209374_s_at (Human Genome U133 Plus 2.0 Array)   212827_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375001
Ensembl peptide - ENSP00000490253
swissprot - A0A1B0GUU9
swissprot - P01871
Ensembl - ENSG00000211899
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IghmENSMUSG00000076617Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)ENSG0000021189027
IGHE / P01854 / immunoglobulin heavy constant epsilonENSG0000021189126
IGHG3 / immunoglobulin heavy constant gamma 3 (G3m marker)ENSG0000021189726
IGHA1 / P01876 / immunoglobulin heavy constant alpha 1ENSG0000021189526
IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)ENSG0000021189325
IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)ENSG0000021189224
IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)ENSG0000021189624


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071756 pentameric IgM immunoglobulin complex IDA
 cellular_componentGO:0071757 hexameric IgM immunoglobulin complex IDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0034987 immunoglobulin receptor binding IDA
 molecular_functionGO:0042834 peptidoglycan binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007312 CD79B / P40259 / CD79b molecule  / complex
 ENSG00000012124 CD22 / P20273 / CD22 molecule  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000095585 BLNK / Q8WV28 / B cell linker  / complex / reaction
 ENSG00000128218 Q9UKI3 / VPREB3 / V-set pre-B cell surrogate light chain 3  / complex / reaction
 ENSG00000128322 IGLL1 / P15814 / immunoglobulin lambda like polypeptide 1  / complex / reaction
 ENSG00000136573 BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000169575 P12018 / VPREB1 / V-set pre-B cell surrogate light chain 1  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / reaction / complex
 ENSG00000105369 CD79A / P11912 / CD79a molecule  / complex
 ENSG00000211899 IGHM / P01871 / immunoglobulin heavy constant mu  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction






 

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