ENSMUSG00000076617


Mus musculus

Features
Gene ID: ENSMUSG00000076617
  
Biological name :Ighm
  
Synonyms : Ighm / immunoglobulin heavy constant mu
  
Possible biological names infered from orthology : P01871
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 113418558
Gene end: 113422730
  
Corresponding Affymetrix probe sets: 1427329_a_at (Mouse Genome 430 2.0 Array)   1427351_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100222
Ensembl peptide - ENSMUSP00000136807
MGI - MGI:96448
swissprot - A0A075B5P6
swissprot - A0A075B6A0
Ensembl - ENSMUSG00000076617
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IGHMENSG00000211899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ighe / P01854* / immunoglobulin heavy constant epsilon*ENSMUSG0000008764227
Igha / IGHA1* / IGHA2* / P01877* / P01876* / immunoglobulin heavy constant alpha 1* / immunoglobulin heavy constant alpha 2 (A2m marker)*ENSMUSG0000009507925
Ighg3 / IGHG1* / IGHG2* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immunoglobulin h...ENSMUSG0000007661524
Ighg2b / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661324
Ighg1 / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immunoglobulin h...ENSMUSG0000007661423
Ighg2c / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661223


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0071756 pentameric IgM immunoglobulin complex IEA
 cellular_componentGO:0071757 hexameric IgM immunoglobulin complex IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IEA
 molecular_functionGO:0042834 peptidoglycan binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm2.1Bgmn/Ighmtm2.1Bgmn
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm2.1Bgmn/Ighmtm2.1Bgmn
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Ighmtm1Cgn/Ighm+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129

Allelic Composition: Ighmtm1Msn/Ighm+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn,Tg(Igh-6)1Msn/?
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Ighmtm1Cgn/Ighm+,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Cgn/Ightm3Tim
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmintm1.1Jhh/Atmintm1.1Jhh,Cd79atm1(cre)Reth/Cd79a+,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-n/Kit+
Genetic Background: involves: WB

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf,Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002363 abnormal spleen marginal sinus morphology "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm2.1Bgmn/Ighmtm2.1Bgmn
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tlr9tm1Aki/Tlr9tm1Aki,Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0003901 abnormal PQ interval "anomaly in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(Igh-6/Igh-V281)3Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt

Allelic Composition: Ighmtm1Cgn/Ighm+,Tg(Igh-6/Igh-V281)3Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(Igh-6/Igh-V125)2Jwt/0,Tg(Igk-C/Igk-V125)1Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

Allelic Composition: Ighmtm1Cgn/Ighm+,Tg(Igh-6/Igh-V125)2Jwt/0,Tg(Igk-C/Igk-V125)1Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa
Genetic Background: B6.Cg-Lcattm1Nsa

Allelic Composition: Ighmtm1Cgn/Ighm+
Genetic Background: NOD.129S2-Ighmtm1Cgn

Allelic Composition: Ighmtm1Cgn/Ighm+,Tg(Igh-6/Igh-V125)2Jwt/0,Tg(Igk-C/Igk-V125)1Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: NOD.129S2-Ighmtm1Cgn/DvsJ

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ightm3Tim
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: NOD.129S2-Ighmtm1Cgn/DvsJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc1re/Mc1re,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(Igh-6/Igh-V125)2Jwt/0,Tg(Igk-C/Igk-V125)1Jwt/0
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: NOD.129S2-Ighmtm1Cgn/DvsJ

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: NOD.129S2-Ighmtm1Cgn/DvsJ

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008164 abnormal B-1a B cell morphology "any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn,Tg(Igh-6)1Msn/?
Genetic Background: B6.129S-Ighmtm1Msn

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn,Tg(Igh-6)1Msn/?
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn,Tg(Igh-6)1Msn/?
Genetic Background: B6.129S-Ighmtm1Msn

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008198 abnormal follicular dendritic cell antigen presentation "anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ighmtm2.1Bgmn/Ighmtm2.1Bgmn
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn
Genetic Background: involves: 129/Sv

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: NOD.129S2-Ighmtm1Cgn/DvsJ

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Sls/Ighmtm1Sls
Genetic Background: Not Specified

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Sls/Ighmtm1Sls
Genetic Background: Not Specified

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Sls/Ighmtm1Sls
Genetic Background: Not Specified

Allelic Composition: Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: B6.129S-Ighmtm1Msn

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn,Tg(Igh-6)1Msn/?
Genetic Background: B6.129S-Ighmtm1Msn

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0010965 decreased compact bone volume 
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic Background: NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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