ENSMUSG00000076614


Mus musculus

Features
Gene ID: ENSMUSG00000076614
  
Biological name :Ighg1
  
Synonyms : Ighg1
  
Possible biological names infered from orthology : IGHG2 / IGHG3 / IGHG4 / immunoglobulin heavy constant gamma 1 (G1m marker) / immunoglobulin heavy constant gamma 2 (G2m marker) / immunoglobulin heavy constant gamma 3 (G3m marker) / immunoglobulin heavy constant gamma 4 (G4m marker) / P01857 / P01859 / P01861
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 113325240
Gene end: 113330523
  
Corresponding Affymetrix probe sets: 1425247_a_at (Mouse Genome 430 2.0 Array)   1425324_x_at (Mouse Genome 430 2.0 Array)   1427756_x_at (Mouse Genome 430 2.0 Array)   1427870_x_at (Mouse Genome 430 2.0 Array)   1442544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100216
Ensembl peptide - ENSMUSP00000141658
MGI - MGI:96446
swissprot - A0A075B5P4
swissprot - A0A0A6YWR2
Ensembl - ENSMUSG00000076614
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IGHG1ENSG00000211896Homo sapiens
 IGHG2ENSG00000211893Homo sapiens
 IGHG3ENSG00000211897Homo sapiens
 IGHG4ENSG00000211892Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ighg3 / IGHG1* / IGHG2* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immunoglobulin h...ENSMUSG0000007661570
Ighg2c / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661269
Ighg2b / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661368
Ighe / P01854* / immunoglobulin heavy constant epsilon*ENSMUSG0000008764236
Ighm / immunoglobulin heavy constant mu / P01871*ENSMUSG0000007661728
Igha / IGHA1* / IGHA2* / P01877* / P01876* / immunoglobulin heavy constant alpha 1* / immunoglobulin heavy constant alpha 2 (A2m marker)*ENSMUSG0000009507925


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002440 abnormal memory B cell morphology/development "anomalous structure, differentiation, or number of cells of the B lymphocyte lineage that do not secrete antibody after an intitial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

Allelic Composition: Ighg1tm1.1Ksho/Ighg1tm1.1Ksho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighg1tm1.1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf4tm1.1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

Allelic Composition: Ighg1tm3Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0008094 absent memory B cells "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighg1tm1(cre)Cgn/Ighg1+,Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl

Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ncoa6tm3Jxu/Ncoa6tm3Jxu,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

Allelic Composition: Ighg1tm1.1Ksho/Ighg1tm1.1Ksho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighg1tm1.1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighg1tm1(cre)Cgn/Ighg1+,Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

Allelic Composition: Ighg1tm3Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1+
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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