ENSG00000211893


Homo sapiens

Features
Gene ID: ENSG00000211893
  
Biological name :IGHG2
  
Synonyms : IGHG2 / immunoglobulin heavy constant gamma 2 (G2m marker) / P01859
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105639559
Gene end: 105644790
  
Corresponding Affymetrix probe sets: 211430_s_at (Human Genome U133 Plus 2.0 Array)   228518_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000374987
Ensembl peptide - ENSP00000493129
swissprot - A0A286YEY4
swissprot - P01859
Ensembl - ENSG00000211893
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 Ighg1ENSMUSG00000076614Mus musculus
 Ighg2bENSMUSG00000076613Mus musculus
 Ighg2cENSMUSG00000076612Mus musculus
 Ighg3ENSMUSG00000076615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHG3 / immunoglobulin heavy constant gamma 3 (G3m marker)ENSG0000021189789
IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)ENSG0000021189688
IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)ENSG0000021189287
IGHE / P01854 / immunoglobulin heavy constant epsilonENSG0000021189133
IGHM / P01871 / immunoglobulin heavy constant muENSG0000021189930
IGHA1 / P01876 / immunoglobulin heavy constant alpha 1ENSG0000021189525
IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)ENSG0000021189025


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149131 P05155 / SERPING1 / serpin family G member 1  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction / complex
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000182326 C1S / P09871 / complement C1s  / complex
 ENSG00000173369 C1QB / P02746 / complement C1q B chain  / complex
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000159189 C1QC / P02747 / complement C1q C chain  / complex
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / reaction / complex
 ENSG00000173372 C1QA / P02745 / complement C1q A chain  / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000166278 C2 / P06681 / complement C2  / reaction
 ENSG00000244731 C4A / P0C0L4 / complement C4A (Rodgers blood group)  / reaction
 ENSG00000224389 C4B / P0C0L5 / complement C4B (Chido blood group)  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex
 ENSG00000159403 C1R / P00736 / complement C1r  / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex






 

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