Manteia

ENSG00000160654

Homo sapiens

Features

Gene ID:	ENSG00000160654

Biological name :	CD3G

Synonyms :	CD3G / CD3g molecule / P09693

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	11
Strand:	1
Band:	q23.3
Gene start:	118344344
Gene end:	118355161

Corresponding Affymetrix probe sets:	206804_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000292144 Ensembl peptide - ENSP00000431445 Ensembl peptide - ENSP00000376621 NCBI entrez gene - 917 See in Manteia. OMIM - 186740 RefSeq - NM_000073 RefSeq - XM_006718941 RefSeq - XM_005271724 RefSeq Peptide - NP_000064 swissprot - B0YIY5 swissprot - P09693 swissprot - J3KNA5 swissprot - A8MUH3 Ensembl - ENSG00000160654

Related genetic diseases (OMIM):	615607 - Immunodeficiency 17, CD3 gamma deficient, 615607

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CD3D	ENSGALG00000007418	Gallus gallus
Cd3g	ENSMUSG00000002033	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CD3D / P04234 / CD3d molecule	ENSG00000167286	37

Protein motifs (from Interpro)

Interpro ID	Name
IPR003110	Phosphorylated immunoreceptor signalling ITAM
IPR003598	Immunoglobulin subtype 2
IPR013783	Immunoglobulin-like fold
IPR015484	CD3 protein, epsilon/gamma/delta subunit
IPR032052	CD3 gamma/delta subunit, Ig-like domain
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0007163	establishment or maintenance of cell polarity	IMP
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0015031	protein transport	IMP
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042110	T cell activation	NAS
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0051260	protein homooligomerization	IMP
biological_process	GO:0061024	membrane organization	TAS
biological_process	GO:0065003	protein-containing complex assembly	NAS
biological_process	GO:0070228	regulation of lymphocyte apoptotic process	IMP
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	NAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030665	clathrin-coated vesicle membrane	TAS
cellular_component	GO:0042101	T cell receptor complex	NAS
cellular_component	GO:0042105	alpha-beta T cell receptor complex	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0030159	receptor signaling complex scaffold activity	NAS
molecular_function	GO:0042608	T cell receptor binding	NAS
molecular_function	GO:0042803	protein homodimerization activity	IMP
molecular_function	GO:0046982	protein heterodimerization activity	IPI

Pathways (from Reactome)

Pathway description

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Downstream TCR signaling

Phosphorylation of CD3 and TCR zeta chains

Translocation of ZAP-70 to Immunological synapse

Generation of second messenger molecules

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

PD-1 signaling

Cargo recognition for clathrin-mediated endocytosis

Clathrin-mediated endocytosis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000007	Autosomal recessive inheritance	"A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]	Show
HP:0000403	Recurrent otitis media		Show
HP:0000964	Eczema	"Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." [HPO:curators]	Show
HP:0001508	Failure to thrive		Show
HP:0001890	Autoimmune hemolytic anemia		Show
HP:0002205	Recurrent respiratory infections		Show
HP:0002242	Abnormality of the intestines		Show
HP:0002721	Immunodeficiency		Show
HP:0003828	Variable expressivity		Show
HP:0005415	Decreased number of CD8+ T cells		Show
HP:0031123	Recurrent gastroenteritis	"Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis." []	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000010610	CD4 / P01730 / CD4 molecule	/ complex / reaction
ENSG00000103653	CSK / P41240 / C-terminal Src kinase	/ reaction
ENSG00000115085	ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70	/ complex / reaction
ENSG00000158477	CD1A / P06126 / CD1a molecule	/ reaction / complex
ENSG00000153563	CD8A / P01732 / CD8a molecule	/ complex
ENSG00000167286	CD3D / P04234 / CD3d molecule	/ reaction / complex
ENSG00000196735	P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	/ reaction / complex
ENSG00000231389	P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	/ reaction / complex
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ reaction / complex
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ reaction / complex
ENSG00000062598	ELMO2 / Q96JJ3 / engulfment and cell motility 2	/ complex / reaction
ENSG00000203747	FCGR3A / P08637 / Fc fragment of IgG receptor IIIa	/ complex
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ reaction
ENSG00000198851	CD3E / P07766 / CD3e molecule	/ reaction / complex
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ reaction / complex
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ reaction
ENSG00000158481	CD1C / P29017 / CD1c molecule	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000213658	LAT / O43561 / linker for activation of T cells	/ reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000166710	B2M / P61769 / beta-2-microglobulin	/ reaction / complex
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ reaction / complex
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ reaction / complex
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ reaction / complex
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ complex / reaction
ENSG00000158485	CD1B / P29016 / CD1b molecule	/ reaction / complex
ENSG00000158473	CD1D / P15813 / CD1d molecule	/ reaction / complex
ENSG00000211892	IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)	/ reaction / complex
ENSG00000237541	P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	/ reaction / complex
ENSG00000155849	ELMO1 / Q92556 / engulfment and cell motility 1	/ reaction / complex
ENSG00000197943	PLCG2 / P16885 / phospholipase C gamma 2	/ reaction / complex
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ complex / reaction
ENSG00000065675	PRKCQ / Q04759 / protein kinase C theta	/ reaction
ENSG00000211799	TRAV19 / T cell receptor alpha variable 19	/ reaction / complex
ENSG00000211896	IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)	/ reaction / complex
ENSG00000204287	P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha	/ reaction / complex
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ complex / reaction
ENSG00000211893	IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)	/ complex / reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ reaction / complex
ENSG00000111679	PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6	/ reaction
ENSG00000172116	CD8B / P10966 / CD8b molecule	/ complex
ENSG00000179295	PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	/ reaction
ENSG00000134242	PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22	/ reaction
ENSG00000150337	FCGR1A / P12314 / Fc fragment of IgG receptor Ia	/ complex
ENSG00000149177	PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr