ENSG00000065675


Homo sapiens

Features
Gene ID: ENSG00000065675
  
Biological name :PRKCQ
  
Synonyms : PRKCQ / protein kinase C theta / Q04759
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p15.1
Gene start: 6427143
Gene end: 6580301
  
Corresponding Affymetrix probe sets: 210038_at (Human Genome U133 Plus 2.0 Array)   210039_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263125
Ensembl peptide - ENSP00000380361
Ensembl peptide - ENSP00000441752
Ensembl peptide - ENSP00000483428
NCBI entrez gene - 5588     See in Manteia.
OMIM - 600448
RefSeq - NM_001323267
RefSeq - NM_006257
RefSeq - XM_017016411
RefSeq - NM_001242413
RefSeq - NM_001282644
RefSeq - NM_001282645
RefSeq - NM_001323265
RefSeq - NM_001323266
RefSeq - XM_005252496
RefSeq - XM_005252497
RefSeq - XM_006717465
RefSeq - XM_017016410
RefSeq Peptide - NP_001310195
RefSeq Peptide - NP_001310196
RefSeq Peptide - NP_006248
RefSeq Peptide - NP_001269574
RefSeq Peptide - NP_001310194
RefSeq Peptide - NP_001229342
RefSeq Peptide - NP_001269573
swissprot - Q04759
swissprot - A0A087X0I9
Ensembl - ENSG00000065675
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcqENSDARG00000034173Danio rerio
 PRKCQENSGALG00000034970Gallus gallus
 PrkcqENSMUSG00000026778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCD / Q05655 / protein kinase C deltaENSG0000016393262
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113241
PRKCH / P24723 / protein kinase C etaENSG0000002707540
PRKCA / P17252 / protein kinase C alphaENSG0000015422939
PRKCG / P05129 / protein kinase C gammaENSG0000012658339
PRKCB / P05771 / protein kinase C betaENSG0000016650139
PRKCI / P41743 / protein kinase C iotaENSG0000016355828
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760628
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522125
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220825
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702025
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851525
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420524
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027264  Protein kinase C, theta
 IPR034668  Novel protein kinase C theta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis ISS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032740 positive regulation of interleukin-17 production ISS
 biological_processGO:0032753 positive regulation of interleukin-4 production ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050870 positive regulation of T cell activation ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0070233 negative regulation of T cell apoptotic process IMP
 biological_processGO:0090330 regulation of platelet aggregation ISS
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response ISS
 biological_processGO:2000570 positive regulation of T-helper 2 cell activation ISS
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Downstream TCR signaling
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
Netrin-1 signaling
G alpha (z) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / complex / reaction
 ENSG00000108370 RGS9 / O75916 / regulator of G protein signaling 9  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000186326 Q6ZS82 / RGS9BP / regulator of G protein signaling 9 binding protein  / reaction
 ENSG00000069966 GNB5 / O14775 / G protein subunit beta 5  / reaction
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / complex / reaction
 ENSG00000092820 EZR / ezrin / P15311  / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / complex / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction






 

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