ENSG00000108370


Homo sapiens

Features
Gene ID: ENSG00000108370
  
Biological name :RGS9
  
Synonyms : O75916 / regulator of G protein signaling 9 / RGS9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q24.1
Gene start: 65100812
Gene end: 65227703
  
Corresponding Affymetrix probe sets: 206518_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405814
Ensembl peptide - ENSP00000490658
Ensembl peptide - ENSP00000463410
Ensembl peptide - ENSP00000262406
Ensembl peptide - ENSP00000396329
NCBI entrez gene - 8787     See in Manteia.
OMIM - 604067
RefSeq - NM_001081955
RefSeq - NM_001165933
RefSeq - NM_003835
RefSeq Peptide - NP_001075424
RefSeq Peptide - NP_001159405
RefSeq Peptide - NP_003826
swissprot - O75916
swissprot - A0A1B0GVU3
swissprot - J3QL70
swissprot - E9PD91
Ensembl - ENSG00000108370
  
Related genetic diseases (OMIM): 608415 - Bradyopsia, 608415
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs9aENSDARG00000037925Danio rerio
 rgs9bENSDARG00000045156Danio rerio
 RGS9ENSGALG00000029610Gallus gallus
 Rgs9ENSMUSG00000020599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGS11 / O94810 / regulator of G protein signaling 11ENSG0000007634436
RGS7 / P49802 / regulator of G protein signaling 7ENSG0000018290126
RGS6 / P49758 / regulator of G protein signaling 6ENSG0000018273226
RGS12 / O14924 / regulator of G protein signaling 12ENSG0000015978821
RGS14 / O43566 / regulator of G protein signaling 14ENSG0000016922015
RGS10 / O43665 / regulator of G protein signaling 10ENSG000001489088


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR015898  G-protein gamma-like domain
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036284  G-protein gamma-like domain superfamily
 IPR036305  RGS domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097381 photoreceptor disc membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000505 Impaired vision 
Show

 HP:0000613 Photophobia "Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light." [HPO:curators]
Show

 HP:0030511 Bradyopsia "Difficulty in seeing moving objects." [pmid:25770143]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000069966 GNB5 / O14775 / G protein subunit beta 5  / complex / reaction
 ENSG00000186326 Q6ZS82 / RGS9BP / regulator of G protein signaling 9 binding protein  / complex
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction






 

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