ENSG00000169220


Homo sapiens

Features
Gene ID: ENSG00000169220
  
Biological name :RGS14
  
Synonyms : O43566 / regulator of G protein signaling 14 / RGS14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 177357837
Gene end: 177372601
  
Corresponding Affymetrix probe sets: 204280_at (Human Genome U133 Plus 2.0 Array)   211021_s_at (Human Genome U133 Plus 2.0 Array)   38290_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386229
Ensembl peptide - ENSP00000422329
NCBI entrez gene - 10636     See in Manteia.
OMIM - 602513
RefSeq - XM_005265795
RefSeq - NM_006480
RefSeq - XM_005265794
RefSeq Peptide - NP_006471
swissprot - O43566
swissprot - H0Y8W3
Ensembl - ENSG00000169220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU019662.1ENSDARG00000060200Danio rerio
 rgs14aENSDARG00000021521Danio rerio
 RGS14ENSGALG00000003113Gallus gallus
 Rgs14ENSMUSG00000052087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGS12 / O14924 / regulator of G protein signaling 12ENSG0000015978843
RGS9 / O75916 / regulator of G protein signaling 9ENSG0000010837017
RGS11 / O94810 / regulator of G protein signaling 11ENSG0000007634413
RGS10 / O43665 / regulator of G protein signaling 10ENSG0000014890813
RGS6 / P49758 / regulator of G protein signaling 6ENSG0000018273210
RGS7 / P49802 / regulator of G protein signaling 7ENSG0000018290110


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif
 IPR003116  Raf-like Ras-binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR030776  Regulator of G-protein signalling 14
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010070 zygote asymmetric cell division IEA
 biological_processGO:0031914 negative regulation of synaptic plasticity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0000922 spindle pole ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0030695 GTPase regulator activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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