ENSMUSG00000052087


Mus musculus

Features
Gene ID: ENSMUSG00000052087
  
Biological name :Rgs14
  
Synonyms : P97492 / Regulator of G-protein signaling 14 / Rgs14
  
Possible biological names infered from orthology : O43566
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55369732
Gene end: 55384687
  
Corresponding Affymetrix probe sets: 10405432 (MoGene1.0st)   1419221_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121508
Ensembl peptide - ENSMUSP00000068731
NCBI entrez gene - 51791     See in Manteia.
MGI - MGI:1859709
RefSeq - NM_016758
RefSeq - XM_011244541
RefSeq Peptide - NP_058038
swissprot - D6RCH4
swissprot - P97492
Ensembl - ENSMUSG00000052087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU019662.1ENSDARG00000060200Danio rerio
 rgs14aENSDARG00000021521Danio rerio
 RGS14ENSGALG00000003113Gallus gallus
 RGS14ENSG00000169220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*ENSMUSG0000002910144
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*ENSMUSG0000002059918
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*ENSMUSG0000003084414
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG0000002418613
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*ENSMUSG0000002121911
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*ENSMUSG0000002652710


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif
 IPR003116  Raf-like Ras-binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR030776  Regulator of G-protein signalling 14
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IMP
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010070 zygote asymmetric cell division IMP
 biological_processGO:0031914 negative regulation of synaptic plasticity IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IDA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0051301 cell division ISO
 biological_processGO:0060291 long-term synaptic potentiation IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0000922 spindle pole ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IDA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity ISO
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0030695 GTPase regulator activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr