ENSMUSG00000030844


Mus musculus

Features
Gene ID: ENSMUSG00000030844
  
Biological name :Rgs10
  
Synonyms : Q9CQE5 / regulator of G-protein signalling 10 / Rgs10
  
Possible biological names infered from orthology : O43665 / regulator of G protein signaling 10
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 128373621
Gene end: 128418758
  
Corresponding Affymetrix probe sets: 10568392 (MoGene1.0st)   1416882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146128
Ensembl peptide - ENSMUSP00000033133
Ensembl peptide - ENSMUSP00000122030
NCBI entrez gene - 67865     See in Manteia.
MGI - MGI:1915115
RefSeq - XM_017312270
RefSeq - NM_026418
RefSeq - XM_006508139
RefSeq - XM_006508140
RefSeq Peptide - NP_080694
swissprot - Q32MD7
swissprot - Q9CQE5
swissprot - D3Z1B6
swissprot - A0A0U1RPU5
Ensembl - ENSMUSG00000030844
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RGS10ENSGALG00000009422Gallus gallus
 RGS10ENSG00000148908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*ENSMUSG0000002910146
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*ENSMUSG0000005208741
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*ENSMUSG0000002059933
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG0000002418628
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*ENSMUSG0000002652727
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*ENSMUSG0000002121925


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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