Manteia - Molecule gene

ENSMUSG00000024186

Mus musculus

Features

Gene ID:	ENSMUSG00000024186

Biological name :	Rgs11

Synonyms :	regulator of G-protein signaling 11 / Rgs11

Possible biological names infered from orthology :	O94810

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	A3.3
Gene start:	26202951
Gene end:	26211324

Corresponding Affymetrix probe sets:	10442968 (MoGene1.0st) 1425245_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025020 Ensembl peptide - ENSMUSP00000113885 NCBI entrez gene - 50782 See in Manteia. MGI - MGI:1354739 RefSeq - XM_017317569 RefSeq - XM_017317566 RefSeq - XM_017317567 RefSeq - XM_017317568 RefSeq - NM_001081069 RefSeq Peptide - NP_001074538 swissprot - G3X8W6 swissprot - E9QNN3 Ensembl - ENSMUSG00000024186

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rgs11	ENSDARG00000037646	Danio rerio
RGS11	ENSGALG00000040648	Gallus gallus
RGS11	ENSG00000076344	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*	ENSMUSG00000020599	52
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*	ENSMUSG00000026527	37
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*	ENSMUSG00000021219	34
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*	ENSMUSG00000029101	24
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*	ENSMUSG00000052087	15
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*	ENSMUSG00000030844	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000591	DEP domain
IPR015898	G-protein gamma-like domain
IPR016137	RGS domain
IPR024066	RGS, subdomain 1/3
IPR036284	G-protein gamma-like domain superfamily
IPR036305	RGS domain superfamily
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
cellular_component	GO:0005834	heterotrimeric G-protein complex	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0031681	G-protein beta-subunit binding	IEA

Pathways (from Reactome)

Pathway description

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003463	abnormal single cell response	"altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Wnk4^tm1Pfi/Wnk4^tm1Pfi Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003732	abnormal outer plexiform layer morphology	"malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Rgs7^tm1Cjch/Rgs7^tm1Cjch Genetic Background: involves: C57BL/6
MP:0004021	abnormal rod electrophysiology	"anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dgat2^tm1Lex/Dgat2^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex,Rgs7^tm1Lex/Rgs7^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex,Rgs7^tm1Cjch/Rgs7^tm1Cjch Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex,Rgs7^tm1.1Kama/Rgs7^tm1.1Kama Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0004022	abnormal cone electrophysiology	"anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dgat2^tm1Lex/Dgat2^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex,Rgs7^tm1Cjch/Rgs7^tm1Cjch Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-4Chlc Genetic Background: involves: 101/Rl * C3H/Rl

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr