ENSMUSG00000029101


Mus musculus

Features
Gene ID: ENSMUSG00000029101
  
Biological name :Rgs12
  
Synonyms : Q8CGE9 / regulator of G-protein signaling 12 / Rgs12
  
Possible biological names infered from orthology : O14924
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 34949445
Gene end: 35039644
  
Corresponding Affymetrix probe sets: 10521337 (MoGene1.0st)   1429380_at (Mouse Genome 430 2.0 Array)   1453129_a_at (Mouse Genome 430 2.0 Array)   1457511_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109920
Ensembl peptide - ENSMUSP00000153391
Ensembl peptide - ENSMUSP00000143979
Ensembl peptide - ENSMUSP00000117158
Ensembl peptide - ENSMUSP00000116913
Ensembl peptide - ENSMUSP00000115064
Ensembl peptide - ENSMUSP00000109924
Ensembl peptide - ENSMUSP00000109923
Ensembl peptide - ENSMUSP00000109922
Ensembl peptide - ENSMUSP00000030984
Ensembl peptide - ENSMUSP00000084970
Ensembl peptide - ENSMUSP00000109919
NCBI entrez gene - 71729     See in Manteia.
MGI - MGI:1918979
RefSeq - XM_006504126
RefSeq - NM_001163512
RefSeq - NM_173402
RefSeq - XM_006504120
RefSeq - XM_006504121
RefSeq - XM_006504122
RefSeq - XM_006504123
RefSeq - XM_006504124
RefSeq - XM_006504125
RefSeq Peptide - NP_775578
RefSeq Peptide - NP_001156984
swissprot - E9Q652
swissprot - Q3TTW9
swissprot - D3Z0G7
swissprot - D3Z0G6
swissprot - D3Z0G5
swissprot - D3YXA5
swissprot - A0A286YDE1
swissprot - A0A0J9YU30
swissprot - F6YRR2
swissprot - E9Q1K7
swissprot - F7B2U5
swissprot - Q8CGE9
Ensembl - ENSMUSG00000029101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs12aENSDARG00000009610Danio rerio
 rgs12bENSDARG00000036774Danio rerio
 RGS12ENSGALG00000015626Gallus gallus
 RGS12ENSG00000159788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*ENSMUSG0000005208717
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*ENSMUSG0000002059910
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*ENSMUSG000000212198
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG000000241868
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*ENSMUSG000000265278
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*ENSMUSG000000308446


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR003109  GoLoco motif
 IPR003116  Raf-like Ras-binding
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030695 GTPase regulator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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