ENSMUSG00000020599


Mus musculus

Features
Gene ID: ENSMUSG00000020599
  
Biological name :Rgs9
  
Synonyms : O54828 / Regulator of G-protein signaling 9 / Rgs9
  
Possible biological names infered from orthology : O75916
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 109225355
Gene end: 109298129
  
Corresponding Affymetrix probe sets: 10392415 (MoGene1.0st)   1418691_at (Mouse Genome 430 2.0 Array)   1426033_at (Mouse Genome 430 2.0 Array)   1439635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102315
Ensembl peptide - ENSMUSP00000102317
Ensembl peptide - ENSMUSP00000020920
Ensembl peptide - ENSMUSP00000099351
NCBI entrez gene - 19739     See in Manteia.
MGI - MGI:1338824
RefSeq - NM_011268
RefSeq - XM_011248828
RefSeq - NM_001165934
RefSeq Peptide - NP_001159406
RefSeq Peptide - NP_035398
swissprot - A2A6V6
swissprot - O54828
swissprot - Q3UUR0
swissprot - A2A6V9
Ensembl - ENSMUSG00000020599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs9aENSDARG00000037925Danio rerio
 rgs9bENSDARG00000045156Danio rerio
 RGS9ENSGALG00000029610Gallus gallus
 RGS9ENSG00000108370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG0000002418636
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*ENSMUSG0000002121925
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*ENSMUSG0000002652725
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*ENSMUSG0000002910120
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*ENSMUSG0000005208714
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*ENSMUSG000000308449


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR015898  G-protein gamma-like domain
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036284  G-protein gamma-like domain superfamily
 IPR036305  RGS domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rgs9tm1(cre)Yql/Rgs9+,Tg(CAG-Ppard*E411P)#Als/0
Genetic Background: B6J.Cg-Rgs9tm1(cre)Yql Tg(CAG-Ppard*E411P)#Als

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Rgs9tm1(cre)Yql/Rgs9+,Tg(CAG-Ppard*E411P)#Als/0
Genetic Background: B6J.Cg-Rgs9tm1(cre)Yql Tg(CAG-Ppard*E411P)#Als

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Oca2p-un/Oca2p-un
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rgs9tm1(cre)Yql/Rgs9+,Tg(CAG-Ppard*E411P)#Als/0
Genetic Background: B6J.Cg-Rgs9tm1(cre)Yql Tg(CAG-Ppard*E411P)#Als

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Rgs9tm1(cre)Yql/Rgs9+,Tg(CAG-Ppard*E411P)#Als/0
Genetic Background: B6J.Cg-Rgs9tm1(cre)Yql Tg(CAG-Ppard*E411P)#Als

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Rgs9tm1(cre)Yql/Rgs9+,Tg(CAG-Ppard*E411P)#Als/0
Genetic Background: B6J.Cg-Rgs9tm1(cre)Yql Tg(CAG-Ppard*E411P)#Als

 MP:0012508 forebrain atrophy "acquired diminution of the size of the forebrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000056043 Q148R9 / Rgs9bp / Regulator of G-protein signaling 9-binding protein / Q6ZS82*  / complex
 ENSMUSG00000032192 Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*  / complex / reaction






 

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