ENSMUSG00000032192


Mus musculus

Features
Gene ID: ENSMUSG00000032192
  
Biological name :Gnb5
  
Synonyms : Gnb5 / guanine nucleotide binding protein (G protein), beta 5 / P62881
  
Possible biological names infered from orthology : G protein subunit beta 5 / O14775
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 75306288
Gene end: 75345876
  
Corresponding Affymetrix probe sets: 10587194 (MoGene1.0st)   1422208_a_at (Mouse Genome 430 2.0 Array)   1447630_x_at (Mouse Genome 430 2.0 Array)   1459520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150492
Ensembl peptide - ENSMUSP00000076155
Ensembl peptide - ENSMUSP00000149938
Ensembl peptide - ENSMUSP00000150270
NCBI entrez gene - 14697     See in Manteia.
MGI - MGI:101848
RefSeq - NM_138719
RefSeq - NM_010313
RefSeq Peptide - NP_034443
RefSeq Peptide - NP_619733
swissprot - Q3UG14
swissprot - P62881
swissprot - A0A1L1STC5
Ensembl - ENSMUSG00000032192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnb5aENSDARG00000099685Danio rerio
 gnb5bENSDARG00000055377Danio rerio
 GNB5ENSGALG00000039307Gallus gallus
 GNB5ENSG00000069966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*ENSMUSG0000002906445
Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*ENSMUSG0000002766945
Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*ENSMUSG0000002343944
Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*ENSMUSG0000002971344
Wdr47 / Q8CGF6 / WD repeat domain 47 / O94967*ENSMUSG0000004038928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001632  G-protein, beta subunit
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016346  Guanine nucleotide-binding protein, beta subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007212 dopamine receptor signaling pathway ISS
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity ISS
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031682 G-protein gamma-subunit binding ISO
 molecular_functionGO:0051087 chaperone binding ISS


Pathways (from Reactome)
Pathway description
G-protein activation
Inactivation, recovery and regulation of the phototransduction cascade
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0002880 opisthotonus "a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnb5flr/Gnb5flr,Myo5aflr/Myo5aflr
Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000056043 Q148R9 / Rgs9bp / Regulator of G-protein signaling 9-binding protein / Q6ZS82*  / complex
 ENSMUSG00000009030 Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*  / complex
 ENSMUSG00000026527 Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*  / complex / reaction
 ENSMUSG00000020599 Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr