ENSMUSG00000029064


Mus musculus

Features
Gene ID: ENSMUSG00000029064
  
Biological name :Gnb1
  
Synonyms : Gnb1 / guanine nucleotide binding protein (G protein), beta 1 / P62874
  
Possible biological names infered from orthology : G protein subunit beta 1 / P62873
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 155491361
Gene end: 155559269
  
Corresponding Affymetrix probe sets: 10511069 (MoGene1.0st)   1417432_a_at (Mouse Genome 430 2.0 Array)   1425908_at (Mouse Genome 430 2.0 Array)   1454696_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130123
Ensembl peptide - ENSMUSP00000030940
Ensembl peptide - ENSMUSP00000101241
Ensembl peptide - ENSMUSP00000135769
Ensembl peptide - ENSMUSP00000135091
Ensembl peptide - ENSMUSP00000135492
NCBI entrez gene - 14688     See in Manteia.
MGI - MGI:95781
RefSeq - NM_008142
RefSeq - XM_017319977
RefSeq - NM_001160016
RefSeq - NM_001160017
RefSeq Peptide - NP_001153488
RefSeq Peptide - NP_001153489
RefSeq Peptide - NP_032168
swissprot - H3BKR2
swissprot - P62874
swissprot - H3BLF7
swissprot - Q3TQ70
Ensembl - ENSMUSG00000029064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnb1aENSDARG00000090454Danio rerio
 gnb1bENSDARG00000104372Danio rerio
 GNB1ENSGALG00000001334Gallus gallus
 GNB1ENSG00000078369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*ENSMUSG0000002971390
Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*ENSMUSG0000002766990
Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*ENSMUSG0000002343983
Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*ENSMUSG0000003219252
Wdr47 / Q8CGF6 / WD repeat domain 47 / O94967*ENSMUSG0000004038928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001632  G-protein, beta subunit
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016346  Guanine nucleotide-binding protein, beta subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007603 phototransduction, visible light ISO
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0010659 cardiac muscle cell apoptotic process ISO
 biological_processGO:0050909 sensory perception of taste IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0070208 protein heterotrimerization IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Activation of the phototransduction cascade
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Olfactory Signaling Pathway
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / complex / reaction
 ENSMUSG00000000001 Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*  / complex / reaction
 ENSMUSG00000000766 Oprm1 / P42866 / opioid receptor, mu 1 / P35372*  / reaction / complex
 ENSMUSG00000040061 Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*  / reaction / complex
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / complex / reaction
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / reaction / complex
 ENSMUSG00000024960 Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*  / reaction / complex
 ENSMUSG00000021675 F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*  / reaction / complex
 ENSMUSG00000025127 Gcgr / Q61606 / Glucagon receptor / P47871*  / reaction
 ENSMUSG00000024462 Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*  / complex
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / complex / reaction
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / complex / reaction
 ENSMUSG00000024524 Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*  / complex / reaction
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / complex / reaction
 ENSMUSG00000027400 Pdyn / prodynorphin / P01213*  / reaction / complex
 ENSMUSG00000028777 Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*  / complex / reaction
 ENSMUSG00000031394 Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...  / complex / reaction
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex / reaction
 ENSMUSG00000029663 Gngt1 / Q61012 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / P63211* / G protein subunit gamma transducin 1*  / complex / reaction
 ENSMUSG00000033717 Adra2a / adrenoceptor alpha 2A / P08913*  / complex / reaction
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / complex / reaction
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / reaction / complex
 ENSMUSG00000032034 Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*  / complex
 ENSMUSG00000041695 Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*  / complex
 ENSMUSG00000050541 Adra1b / adrenoceptor alpha 1B / P35368*  / reaction / complex
 ENSMUSG00000057614 Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*  / complex / reaction
 ENSMUSG00000045875 Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*  / complex / reaction
 ENSMUSG00000027765 P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000042529 Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*  / complex
 ENSMUSG00000027335 Adra1d / adrenoceptor alpha 1D / P25100*  / complex / reaction
 ENSMUSG00000044216 Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*  / complex
 ENSMUSG00000034881 P30987 / Tbxa2r / thromboxane A2 receptor / P21731*  / reaction / complex
 ENSMUSG00000038026 Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*  / complex
 ENSMUSG00000020573 Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*  / complex / reaction
 ENSMUSG00000020901 Pik3r5 / Q5SW28 / Phosphoinositide 3-kinase regulatory subunit 5 / Q8WYR1*  / reaction / complex
 ENSMUSG00000044708 Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSMUSG00000046207 Pik3r6 / Q3U6Q4 / Phosphoinositide 3-kinase regulatory subunit 6 / Q5UE93*  / complex / reaction
 ENSMUSG00000051497 Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*  / complex
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000062609 Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*  / complex
 ENSMUSG00000032562 Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction
 ENSMUSG00000043301 Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*  / complex
 ENSMUSG00000009030 Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*  / complex
 ENSMUSG00000026824 Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*  / complex
 ENSMUSG00000043017 Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*  / complex / reaction
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / reaction / complex
 ENSMUSG00000050147 F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*  / complex / reaction
 ENSMUSG00000031748 Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*  / complex
 ENSMUSG00000040009 Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*  / complex / reaction
 ENSMUSG00000009108 Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*  / complex
 ENSMUSG00000045318 Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*  / complex / reaction
 ENSMUSG00000058620 Adra2b / adrenoceptor alpha 2B / P18089*  / complex / reaction
 ENSMUSG00000036353 P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*  / complex / reaction
 ENSMUSG00000051177 Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*  / complex / reaction
 ENSMUSG00000058831 Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*  / reaction / complex
 ENSMUSG00000039809 Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*  / complex






 

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