ENSMUSG00000040009


Mus musculus

Features
Gene ID: ENSMUSG00000040009
  
Biological name :Gnaz
  
Synonyms : Gnaz / guanine nucleotide binding protein, alpha z subunit / O70443
  
Possible biological names infered from orthology : G protein subunit alpha z / P19086
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 74967177
Gene end: 75016907
  
Corresponding Affymetrix probe sets: 10363962 (MoGene1.0st)   1426517_at (Mouse Genome 430 2.0 Array)   1435268_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036087
Ensembl peptide - ENSMUSP00000124639
NCBI entrez gene - 14687     See in Manteia.
MGI - MGI:95780
RefSeq - XM_006513237
RefSeq - NM_001358848
RefSeq - NM_010311
RefSeq - XM_006513235
RefSeq - XM_006513236
RefSeq Peptide - NP_001345777
RefSeq Peptide - NP_034441
swissprot - Q542R8
swissprot - O70443
Ensembl - ENSMUSG00000040009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAZENSDARG00000099844Danio rerio
 GNAZENSGALG00000006719Gallus gallus
 GNAZENSG00000128266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761467
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000166
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256265
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877758
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174857
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910856
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483754
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463948
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469747
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478146
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479242
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014941
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061139


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031821 G-protein coupled serotonin receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
G alpha (z) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033717 Adra2a / adrenoceptor alpha 2A / P08913*  / reaction / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000045318 Adra2c / Q01337 / Alpha-2C adrenergic receptor / P18825* / adrenoceptor alpha 2C*  / complex / reaction
 ENSMUSG00000058620 Adra2b / adrenoceptor alpha 2B / P18089*  / reaction / complex






 

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