ENSMUSG00000009108


Mus musculus

Features
Gene ID: ENSMUSG00000009108
  
Biological name :Gnat2
  
Synonyms : Gnat2 / guanine nucleotide binding protein, alpha transducing 2 / P50149
  
Possible biological names infered from orthology : G protein subunit alpha transducin 2 / P19087
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.3
Gene start: 108092789
Gene end: 108101432
  
Corresponding Affymetrix probe sets: 10495259 (MoGene1.0st)   1422907_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121533
Ensembl peptide - ENSMUSP00000123125
Ensembl peptide - ENSMUSP00000053818
Ensembl peptide - ENSMUSP00000120425
NCBI entrez gene - 14686     See in Manteia.
MGI - MGI:95779
RefSeq - XM_006501011
RefSeq - NM_008141
RefSeq - XM_006501008
RefSeq - XM_006501010
RefSeq Peptide - NP_032167
swissprot - A2AE31
swissprot - P50149
swissprot - A2AE33
swissprot - F6QPU5
swissprot - A2AE32
Ensembl - ENSMUSG00000009108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnat2ENSDARG00000042529Danio rerio
 GNAT2ENSGALG00000038084Gallus gallus
 GNAT2ENSG00000134183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877780
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483780
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000169
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761469
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256268
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174859
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000956
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478151
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463951
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469749
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479243
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014940
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061139


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0007602 phototransduction TAS
 biological_processGO:0009642 response to light intensity IEA
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception ISO
 cellular_componentGO:0001750 photoreceptor outer segment IBA
 cellular_componentGO:0001917 photoreceptor inner segment IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
Ca2+ pathway
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031394 Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...  / reaction / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / reaction / complex
 ENSMUSG00000025386 Pde6g / P09174 / phosphodiesterase 6G, cGMP-specific, rod, gamma / P18545* / phosphodiesterase 6G*  / reaction / complex
 ENSMUSG00000029491 Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex
 ENSMUSG00000024575 Pde6a / phosphodiesterase 6A / P16499*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000058831 Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr