ENSMUSG00000032562


Mus musculus

Features
Gene ID: ENSMUSG00000032562
  
Biological name :Gnai2
  
Synonyms : Gnai2 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P08752
  
Possible biological names infered from orthology : G protein subunit alpha i2 / P04899
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107614125
Gene end: 107635367
  
Corresponding Affymetrix probe sets: 10596704 (MoGene1.0st)   1419449_a_at (Mouse Genome 430 2.0 Array)   1435652_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141472
Ensembl peptide - ENSMUSP00000142326
Ensembl peptide - ENSMUSP00000142060
Ensembl peptide - ENSMUSP00000141929
Ensembl peptide - ENSMUSP00000057543
NCBI entrez gene - 14678     See in Manteia.
MGI - MGI:95772
RefSeq - XM_006511637
RefSeq - NM_008138
RefSeq Peptide - NP_032164
swissprot - A0A0A6YXC2
swissprot - A0A0A6YXN0
swissprot - P08752
swissprot - A0A0A6YWA9
Ensembl - ENSMUSG00000032562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnai2aENSDARG00000018174Danio rerio
 gnai2bENSDARG00000017294Danio rerio
 GNAI2ENSGALG00000035645Gallus gallus
 GNAI2ENSG00000114353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761488
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000185
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910868
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174868
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483766
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877766
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000965
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469751
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463950
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478150
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479244
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061139
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014939


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISA
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IMP
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0008283 cell proliferation IPI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051301 cell division ISO
 biological_processGO:0051924 regulation of calcium ion transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Gnai2tm2.1Lbi/Gnai2tm2.1Lbi,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gnai2tm2.1Lbi/Gnai2+,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gnai2tm2.1Lbi/Gnai2tm2.1Lbi,Gnai3tm1Lbi/Gnai3tm1Lbi,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: either: 129/Sv or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: either: 129/Sv or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001665 chronic diarrhea "prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm2.1Rneu/Gnai2tm2.1Rneu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(cre/ert2)Tyj Gnai2tm2.1Rneu

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: either: 129/Sv or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: either: 129/Sv or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: either: 129/Sv or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gnai2tm2.1Rneu/Gnai2tm2.1Rneu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(cre/ert2)Tyj Gnai2tm2.1Rneu

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm2.1Lbi/Gnai2tm2.1Lbi,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Tg(WTbeta2)4Wjk/0
Genetic Background: B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Gnai1tm1Drs/Gnai1tm1Drs,Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1.1Rneu/Gnai2tm1.1Rneu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024524 Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000036353 P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*  / reaction / complex






 

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