ENSMUSG00000024639


Mus musculus

Features
Gene ID: ENSMUSG00000024639
  
Biological name :Gnaq
  
Synonyms : Gnaq / guanine nucleotide binding protein, alpha q polypeptide / P21279
  
Possible biological names infered from orthology : G protein subunit alpha q / P50148
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 16132831
Gene end: 16387463
  
Corresponding Affymetrix probe sets: 10461844 (MoGene1.0st)   1428938_at (Mouse Genome 430 2.0 Array)   1428939_s_at (Mouse Genome 430 2.0 Array)   1428940_at (Mouse Genome 430 2.0 Array)   1429559_at (Mouse Genome 430 2.0 Array)   1447593_x_at (Mouse Genome 430 2.0 Array)   1450115_at (Mouse Genome 430 2.0 Array)   1455729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025541
NCBI entrez gene - 14682     See in Manteia.
MGI - MGI:95776
RefSeq - NM_008139
RefSeq Peptide - NP_032165
swissprot - P21279
swissprot - Q3UHH5
Ensembl - ENSMUSG00000024639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnaqENSDARG00000011487Danio rerio
 GNAQENSGALG00000015177Gallus gallus
 GNAQENSG00000156052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478189
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469781
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479258
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761451
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000150
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910850
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877749
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483749
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256249
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174849
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000947
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061146
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014943


Protein motifs (from Interpro)
Interpro ID Name
 IPR000654  G-protein alpha subunit, group Q
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001508 action potential IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007215 glutamate receptor signaling pathway IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016322 neuron remodeling IMP
 biological_processGO:0021884 forebrain neuron development IMP
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045634 regulation of melanocyte differentiation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IGI
 biological_processGO:0070208 protein heterotrimerization ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031826 type 2A serotonin receptor binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity ISO


Pathways (from Reactome)
Pathway description
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Platelet sensitization by LDL
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000104 abnormal sphenoid bone morphology "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000440 domed skull 
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: GnaqMhdadsk10/GnaqMhdadsk10
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0000678 abnormal parathyroid gland morphology "anomalous structure of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: GnaqMhdadsk10/GnaqMhdadsk10
Genetic Background: C3HeB/FeJ-GnaqDsk10

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL

 MP:0001562 abnormal circulating calcium level "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002249 abnormal larynx morphology "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0002985 abnormal urine calcium level "any change in the level of excretion of calcium in the urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004452 abnormal pterygoid process morphology "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: GnaqMhdadsk10/GnaqMhdadsk10
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0009385 abnormal dermal pigmentation "anomaly in coloration of the dermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0009387 abnormal epidermal pigmentation "anomaly in coloration of the epidermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0010326 malleus hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010640 ventricular myocardium compact layer hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

Allelic Composition: Gnaqtm2.1Soff/Gnaqtm2.1Soff
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: GnaqMhdadsk10/GnaqMhdadsk10
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: GnaqMhdadsk10/GnaqMhdadsk10
Genetic Background: C3HeB/FeJ-GnaqDsk10

Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0012045 increased susceptibility to hypertension "more likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [MGI:Nicole]
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0020106 decreased nitrate level "decreased level of nitrate ion in fluids and tissues" [GOC:NV]
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
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Allelic Composition: CrygdLop12/CrygdLop12
Genetic Background: involves: BALB/cJ * SJL/J

 MP:0030107 incus hypoplasia "underdevelopment or reduced size, usually due to reduced cell number, of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [MGI:anna]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0030128 stapes hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna]
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0030299 lower jaw to upper jaw transformation "homeotic transformation of lower jaw (mandibular) elements into upper jaw-like (maxillary) structures" [MGI:anna, PMID:22560091]
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040061 Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*  / reaction / complex
 ENSMUSG00000024960 Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*  / reaction / complex
 ENSMUSG00000021675 F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*  / reaction / complex
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSMUSG00000051177 Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000027765 P2ry1 / P49650 / purinergic receptor P2Y, G-protein coupled 1 / P47900* / purinergic receptor P2Y1*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000034881 P30987 / Tbxa2r / thromboxane A2 receptor / P21731*  / complex / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction / complex
 ENSMUSG00000039943 Plcb4 / phospholipase C, beta 4 / Q15147*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000046159 Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*  / reaction
 ENSMUSG00000050147 F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*  / complex / reaction






 

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