ENSMUSG00000034837


Mus musculus

Features
Gene ID: ENSMUSG00000034837
  
Biological name :Gnat1
  
Synonyms : Gnat1 / guanine nucleotide binding protein, alpha transducing 1 / P20612
  
Possible biological names infered from orthology : G protein subunit alpha transducin 1 / P11488
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107674474
Gene end: 107679712
  
Corresponding Affymetrix probe sets: 10596737 (MoGene1.0st)   1460212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141571
Ensembl peptide - ENSMUSP00000010205
NCBI entrez gene - 14685     See in Manteia.
MGI - MGI:95778
RefSeq - NM_008140
RefSeq Peptide - NP_032166
swissprot - A0A0A6YWJ0
swissprot - P20612
Ensembl - ENSMUSG00000034837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnat1ENSDARG00000044199Danio rerio
 GNAT1ENSGALG00000028697Gallus gallus
 GNAT1ENSG00000114349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910881
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877780
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761469
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256267
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000165
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174860
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000955
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469751
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463950
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478150
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479244
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014940
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061139


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0007603 phototransduction, visible light IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0009642 response to light intensity IEA
 biological_processGO:0016056 rhodopsin mediated signaling pathway IEA
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0050917 sensory perception of umami taste IMP
 biological_processGO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0071257 cellular response to electrical stimulus IMP
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002003 meiotic pupils "charcterized by contraction of the pupils " [J:17194]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: irdc/irdc,Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

Allelic Composition: Abca4tm2.1Kpal/Abca4tm2.1Kpal,Gnat1tm1Clma/Gnat1tm1Clma
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N

 MP:0004213 abnormal unami taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something unami (savory) by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gngt1tm1Dgen/Gngt1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gngt1tm1Dgen/Gngt1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Cxd/Brca1tm1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca4tm2.1Kpal/Abca4tm2.1Kpal,Gnat1tm1Clma/Gnat1tm1Clma
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029663 Gngt1 / Q61012 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / P63211* / G protein subunit gamma transducin 1*  / complex
 ENSMUSG00000024575 Pde6a / phosphodiesterase 6A / P16499*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000029491 Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex
 ENSMUSG00000025386 Pde6g / P09174 / phosphodiesterase 6G, cGMP-specific, rod, gamma / P18545* / phosphodiesterase 6G*  / complex
 ENSMUSG00000020936 Nmt1 / O70310 / Glycylpeptide N-tetradecanoyltransferase 1 / P30419* / N-myristoyltransferase 1*  / reaction
 ENSMUSG00000031394 Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...  / reaction / complex
 ENSMUSG00000005813 Metap1 / Q8BP48 / Methionine aminopeptidase 1 / P53582* / methionyl aminopeptidase 1*  / reaction
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / reaction / complex
 ENSMUSG00000036112 Metap2 / O08663 / methionine aminopeptidase 2 / P50579* / methionyl aminopeptidase 2*  / reaction
 ENSMUSG00000026643 Nmt2 / O70311 / Glycylpeptide N-tetradecanoyltransferase 2 / O60551* / N-myristoyltransferase 2*  / reaction
 ENSMUSG00000058831 Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*  / complex / reaction






 

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