ENSMUSG00000025386


Mus musculus

Features
Gene ID: ENSMUSG00000025386
  
Biological name :Pde6g
  
Synonyms : P09174 / Pde6g / phosphodiesterase 6G, cGMP-specific, rod, gamma
  
Possible biological names infered from orthology : P18545 / phosphodiesterase 6G
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120447605
Gene end: 120453500
  
Corresponding Affymetrix probe sets: 10393793 (MoGene1.0st)   1425100_a_at (Mouse Genome 430 2.0 Array)   1450453_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026452
NCBI entrez gene - 18588     See in Manteia.
MGI - MGI:97526
RefSeq - XM_006532455
RefSeq - NM_012065
RefSeq Peptide - NP_036197
swissprot - P09174
swissprot - Q542R6
Ensembl - ENSMUSG00000025386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde6gbENSDARG00000101984Danio rerio
 PDE6GENSGALG00000004514Gallus gallus
 PDE6GENSG00000185527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde6h / P61249 / phosphodiesterase 6H, cGMP-specific, cone, gamma / Q13956* / phosphodiesterase 6H*ENSMUSG0000006433078


Protein motifs (from Interpro)
Interpro ID Name
 IPR006952  Retinal cGMP phosphodiesterase, gamma subunit
 IPR037030  Retinal cGMP phosphodiesterase, gamma subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / complex
 ENSMUSG00000024575 Pde6a / phosphodiesterase 6A / P16499*  / complex
 ENSMUSG00000025386 Pde6g / P09174 / phosphodiesterase 6G, cGMP-specific, rod, gamma / P18545* / phosphodiesterase 6G*  / complex
 ENSMUSG00000029491 Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*  / complex
 ENSMUSG00000009108 Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*  / reaction / complex






 

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