Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0001004	abnormal photoreceptor morphology	"structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Tg(OPN1LW-DT)1Mame/? Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J
MP:0001005	abnormal rod morphology	"structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J
MP:0001006	abnormal cone morphology	"structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Stat5a^tm2Mam Stat5b^tm1Mam/Del(11Stat5a-Stat5b)1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: A/?,Tyr^c/Tyr^em6Ove Genetic Background: involves: C57BL/6 * FVB Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmp8b^tm1Blh/Bmp8b^tm1Blh Genetic Background: either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6) Allelic Composition: Pde6b^atrd1/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: either: C.Cg-Pde6b^rd1 or C3.Cg-Pde6b^rd1 Allelic Composition: Pde6b^rd1/Pde6b^rd1,Tg(OPN1LW-DT)1Mame/? Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J
MP:0001326	retinal degeneration	"pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Bmp8b^tm1Blh/Bmp8b^tm1Blh Genetic Background: either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6) Allelic Composition: Pde6b^rd1-2J/Pde6b^rd1-2J Genetic Background: C57BL/6J-Pde6b^rd1-2J/J Allelic Composition: Pde6b^atrd1/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd1/Pde6b^atrd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd3/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd3/Pde6b^atrd3 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-1H/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-2H/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-3H/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-4H/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-1H/Pde6b^rd1-1H Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-2H/Pde6b^rd1-2H Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-3H/Pde6b^rd1-3H Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1-4H/Pde6b^rd1-4H Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1,Rho^{tm2(RHO/GFP)Jhw}/Rho⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB) Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J Allelic Composition: Pde6b^rd1/Pde6b^rd1,Tg(OPN1LW-DT)1Mame/? Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: C3H/HeJ Allelic Composition: Pde6b^rd1/Pde6b^rgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H
MP:0001327	reduced retinal photoreceptor cell number	"fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: ABJ/LeJ-Prkcq^rpea1/Boc Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Bmp8b^tm1Blh/Bmp8b^tm1Blh Genetic Background: either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6)
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pde6b^atrd1/Pde6b^atrd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Pde6b^rd1-2J/Pde6b^rd1-2J Genetic Background: C57BL/6J-Pde6b^rd1-2J/J Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J
MP:0002864	abnormal ocular fundus morphology	"malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: ABJ/LeJ-Prkcq^rpea1/Boc Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0003099	retinal detachment	"detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0003728	abnormal photoreceptor layer	"malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Pde6g^tm1Goff/Pde6g^tm1Goff Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
MP:0003729	abnormal photoreceptor outer segments	"malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0003731	abnormal outer nuclear layer morphology	"malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 Allelic Composition: Pde6b^rd1/Pde6b^rd1,Tg(OPN1LW-DT)1Mame/? Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: C3H/HeJ
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0004021	abnormal rod electrophysiology	"anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
MP:0004022	abnormal cone electrophysiology	"anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
MP:0005253	abnormal eye physiology	"anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay,Pde6b^rd1/Pde6b^rd1 Genetic Background: B6.Cg-Pde6b^rd1 Opn4^tm1Skay
MP:0005258	ocular hypertension	"abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: ABJ/LeJ-Prkcq^rpea1/Boc Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0005547	abnormal Muller cell morphology	"anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: either: C.Cg-Pde6b^rd1 or C3.Cg-Pde6b^rd1 Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prph2^Rd2/Prph2^Rd2 Genetic Background: either: C.Cg-Pde6b^rd1 Prph2^Rd2 or C3.Cg-Pde6b^rd1 Prph2^Rd2
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Pde6b^rd1-2J/Pde6b^rd1-2J Genetic Background: C57BL/6J-Pde6b^rd1-2J/J Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J Allelic Composition: Pde6b^rd1/Pde6b^rd1,Pde6g^tm1Goff/Pde6g^tm1Goff Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster) Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
MP:0006149	blurred vision	"loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pde6b^atrd1/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd1/Pde6b^atrd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd3/Pde6b^atrd3 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H
MP:0006243	abnormal pupil dilation reaction to light	"the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-e/Kit^W-e Genetic Background: involves: 101/H * C3H/HeH Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1/SvImJ * C57BL/6
MP:0006298	abnormal platelet activation	"anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dysf^im/Dysf^im,Large1^myd/Large1^myd Genetic Background: involves: C57BL/6 * SJL/J
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: ABJ/LeJ-Prkcq^rpea1/Boc Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0008259	abnormal optic disc morphology	"any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^atrd1/Pde6b^atrd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd3/Pde6b^atrd3 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H
MP:0008446	decreased retinal cone cell number	"reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0008450	retinal photoreceptor degeneration	"a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prph2^Rd2/Prph2^Rd2 Genetic Background: either: C.Cg-Pde6b^rd1 Prph2^Rd2 or C3.Cg-Pde6b^rd1 Prph2^Rd2 Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
MP:0008451	retinal rod cell degeneration	"a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]	Show Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J
MP:0008453	decreased retinal rod cell number	"reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J
MP:0008454	absent retinal rod cells	"absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]	Show Allelic Composition: Kit^W-e/Kit^W-e Genetic Background: involves: 101/H * C3H/HeH Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Tg(OPN1LW-DT)1Mame/? Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J
MP:0008515	thin retinal outer nuclear layer	"reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ Allelic Composition: Pde6b^atrd1/Pde6b^atrd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^atrd2 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd2/Pde6b^rd1 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^atrd3/Pde6b^atrd3 Genetic Background: involves: BALB/cAnN * C3H/HeN Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: either: C.Cg-Pde6b^rd1 or C3.Cg-Pde6b^rd1 Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: C3H
MP:0008517	thick retinal outer nuclear layer	"increased thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J
MP:0008518	retinal outer nuclear layer degeneration	"a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^rd10/Pde6b^rd10 Genetic Background: B6.CXB1-Pde6b^rd10/J Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: B.C3-Pde6b^rd1 Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prph2^Rd2/Prph2^Rd2 Genetic Background: involves: C3Hf/HeA * C57BL/LiA * O20/A
MP:0008519	thin retinal outer plexiform layer	"reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ
MP:0008520	disorganized retinal outer plexiform layer	"a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbn2^fp-2J/Fbn2^fp-2J Genetic Background: involves: C57BL/6J * C.B10-H2^b/LiMcdJ
MP:0008585	absent photoreceptor outer segment	"absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prph2^Rd2/Prph2^Rd2 Genetic Background: either: C.Cg-Pde6b^rd1 Prph2^Rd2 or C3.Cg-Pde6b^rd1 Prph2^Rd2 Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: C3H/HeJ
MP:0009274	buphthalmos	"abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: ABJ/LeJ-Prkcq^rpea1/Boc Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0009549	impaired platelet aggregation	"decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]	Show Allelic Composition: Dysf^im/Dysf^im,Large1^myd/Large1^myd Genetic Background: involves: C57BL/6 * SJL/J
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J Allelic Composition: Pde6b^atrd1/Pde6b^tm1Eye Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
MP:0011279	decreased ear pigmentation	"visually detectable dilution of pigment present in the outer ear" [MGI:csmith]	Show Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0011831	abnormal visual contrast sensitivity	"any abnormality in the ability to distinguish between increments of light versus dark" [MGI:smb]	Show Allelic Composition: Lexm^Retro/Lexm⁺ Genetic Background: involves: C57BL/6J
MP:0011965	decreased total retina thickness	"decreased width of the retina through the center plane" [MGI:csmith]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1 Genetic Background: either: C.Cg-Pde6b^rd1 or C3.Cg-Pde6b^rd1
MP:0020442	serous retinal detachment	"a retinal detachment resulting from accumulation of fluid between the retina and retinal pigment epithelium in the absence of a retinal tear" [doi: 10.1167/iovs.15-17495]	Show Allelic Composition: Pde6b^rd1/Pde6b^rd1,Prkcq^rpea1/Prkcq^rpea1 Genetic Background: B6.ABJ-Prkcq^rpea1 Pde6b^rd1/Boc
MP:0020473	abnormal circadian behavior phase	"anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0020476	abnormal circardian behavior entrainment	"anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]	Show Allelic Composition: Opn4^tm1Skay/Opn4^tm1Skay,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129S1/SvImJ * C57BL/6
MP:0020477	abnormal locomotor circadian rhythm	"any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]	Show Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn,Cry2^tm1Asn/Cry2^tm1Asn,Pde6b^rd1/Pde6b^rd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000029491