ENSMUSG00000075270


Mus musculus

Features
Gene ID: ENSMUSG00000075270
  
Biological name :Pde11a
  
Synonyms : Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / P0C1Q2 / Pde11a
  
Possible biological names infered from orthology : phosphodiesterase 11A / Q9HCR9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 75989141
Gene end: 76338774
  
Corresponding Affymetrix probe sets: 10483828 (MoGene1.0st)   1432999_at (Mouse Genome 430 2.0 Array)   1454430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097572
Ensembl peptide - ENSMUSP00000115662
Ensembl peptide - ENSMUSP00000117451
NCBI entrez gene - 241489     See in Manteia.
MGI - MGI:3036251
RefSeq - XM_006499453
RefSeq - XM_006499454
RefSeq - NM_001081033
RefSeq Peptide - NP_001074502
swissprot - P0C1Q2
swissprot - F7AAG1
swissprot - F6SXR7
Ensembl - ENSMUSG00000075270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde11aENSDARG00000063732Danio rerio
 ENSGALG00000042374Gallus gallus
 PDE11AENSG00000128655Homo sapiens
 PDE11AENSG00000284741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396537
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949129
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457528
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499227
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019525
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065325
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386824
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174114
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067114
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111913


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0046069 cGMP catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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