ENSMUSG00000041119


Mus musculus

Features
Gene ID: ENSMUSG00000041119
  
Biological name :Pde9a
  
Synonyms : High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O70628 / Pde9a
  
Possible biological names infered from orthology : O76083 / phosphodiesterase 9A
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 31386234
Gene end: 31476310
  
Corresponding Affymetrix probe sets: 10443786 (MoGene1.0st)   1449403_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117065
Ensembl peptide - ENSMUSP00000121126
Ensembl peptide - ENSMUSP00000121003
Ensembl peptide - ENSMUSP00000118869
Ensembl peptide - ENSMUSP00000117911
Ensembl peptide - ENSMUSP00000117611
Ensembl peptide - ENSMUSP00000117364
Ensembl peptide - ENSMUSP00000038005
Ensembl peptide - ENSMUSP00000115188
Ensembl peptide - ENSMUSP00000116724
NCBI entrez gene - 18585     See in Manteia.
MGI - MGI:1277179
RefSeq - XM_017317319
RefSeq - NM_001163748
RefSeq - NM_008804
RefSeq - XM_006523821
RefSeq Peptide - NP_032830
RefSeq Peptide - NP_001157220
swissprot - F7APE3
swissprot - D6RGP8
swissprot - O70628
swissprot - D6RH57
swissprot - D6RFN9
swissprot - D6REE8
swissprot - D3YTQ4
swissprot - D3Z408
swissprot - F6ZAU1
Ensembl - ENSMUSG00000041119
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ378016.1ENSDARG00000108939Danio rerio
 pde9aENSDARG00000060280Danio rerio
 pde9alENSDARG00000076650Danio rerio
 PDE9AENSGALG00000016186Gallus gallus
 PDE9AENSG00000160191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457525
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949125
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065324
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019524
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527023
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499223
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067122
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396522
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174121
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386819


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0019934 cGMP-mediated signaling IEA
 biological_processGO:0046068 cGMP metabolic process ISO
 biological_processGO:0046069 cGMP catabolic process ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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