ENSMUSG00000041741


Mus musculus

Features
Gene ID: ENSMUSG00000041741
  
Biological name :Pde3a
  
Synonyms : Pde3a / phosphodiesterase 3A, cGMP inhibited / Q9Z0X4
  
Possible biological names infered from orthology : phosphodiesterase 3A / Q14432
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G2
Gene start: 141249269
Gene end: 141507448
  
Corresponding Affymetrix probe sets: 10542575 (MoGene1.0st)   1431913_a_at (Mouse Genome 430 2.0 Array)   1431914_at (Mouse Genome 430 2.0 Array)   1450284_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038749
NCBI entrez gene - 54611     See in Manteia.
MGI - MGI:1860764
RefSeq - XM_011241595
RefSeq - NM_018779
RefSeq - XM_006506979
RefSeq Peptide - NP_061249
swissprot - Q9Z0X4
swissprot - B2RR84
Ensembl - ENSMUSG00000041741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde3aENSDARG00000004227Danio rerio
 PDE3AENSGALG00000013143Gallus gallus
 PDE3AENSG00000172572Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067142
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499214
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949113
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457513
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065311
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019511
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527011
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386810
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396510
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111910


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0019933 cAMP-mediated signaling ISO
 biological_processGO:0019934 cGMP-mediated signaling ISO
 biological_processGO:0040020 regulation of meiotic nuclear division IDA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability ISO
 biological_processGO:0043117 positive regulation of vascular permeability ISO
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060282 positive regulation of oocyte development IGI
 biological_processGO:0071321 cellular response to cGMP ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IEA
 molecular_functionGO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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