ENSMUSG00000053965


Mus musculus

Features
Gene ID: ENSMUSG00000053965
  
Biological name :Pde5a
  
Synonyms : cGMP-specific 3,5-cyclic phosphodiesterase / Pde5a / Q8CG03
  
Possible biological names infered from orthology : O76074 / phosphodiesterase 5A
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 122728947
Gene end: 122859374
  
Corresponding Affymetrix probe sets: 10495794 (MoGene1.0st)   1455970_at (Mouse Genome 430 2.0 Array)   1458341_x_at (Mouse Genome 430 2.0 Array)   1460118_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143042
Ensembl peptide - ENSMUSP00000069011
NCBI entrez gene - 242202     See in Manteia.
MGI - MGI:2651499
RefSeq - NM_153422
RefSeq - XM_006501481
RefSeq Peptide - NP_700471
swissprot - A0A0G2JF67
swissprot - Q8CG03
Ensembl - ENSMUSG00000053965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde5abENSDARG00000051915Danio rerio
 PDE5AENSGALG00000011982Gallus gallus
 PDE5AENSG00000138735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527040
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949130
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499229
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457528
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386827
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065325
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019525
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067114
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174114
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111914


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IGI
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IMP
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IC
 biological_processGO:0046068 cGMP metabolic process IMP
 biological_processGO:0046069 cGMP catabolic process ISO
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IMP
 biological_processGO:0055119 relaxation of cardiac muscle IMP
 biological_processGO:0060282 positive regulation of oocyte development IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030553 cGMP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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