ENSG00000138735


Homo sapiens

Features
Gene ID: ENSG00000138735
  
Biological name :PDE5A
  
Synonyms : O76074 / PDE5A / phosphodiesterase 5A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q26
Gene start: 119494395
Gene end: 119628991
  
Corresponding Affymetrix probe sets: 1553175_s_at (Human Genome U133 Plus 2.0 Array)   1556786_at (Human Genome U133 Plus 2.0 Array)   1556787_s_at (Human Genome U133 Plus 2.0 Array)   1562227_at (Human Genome U133 Plus 2.0 Array)   1562228_s_at (Human Genome U133 Plus 2.0 Array)   206757_at (Human Genome U133 Plus 2.0 Array)   227088_at (Human Genome U133 Plus 2.0 Array)   240088_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264805
Ensembl peptide - ENSP00000377957
Ensembl peptide - ENSP00000416309
Ensembl peptide - ENSP00000425810
Ensembl peptide - ENSP00000347046
NCBI entrez gene - 8654     See in Manteia.
OMIM - 603310
RefSeq - XM_017008791
RefSeq - NM_001083
RefSeq - NM_033430
RefSeq - NM_033437
RefSeq Peptide - NP_236914
RefSeq Peptide - NP_001074
RefSeq Peptide - NP_246273
swissprot - O76074
swissprot - G5E9C5
swissprot - C9JGT3
swissprot - H0YA14
Ensembl - ENSG00000138735
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde5abENSDARG00000051915Danio rerio
 PDE5AENSGALG00000011982Gallus gallus
 Pde5aENSMUSG00000053965Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE11A / Q9HCR9 / phosphodiesterase 11AENSG0000012865540
PDE11A / phosphodiesterase 11AENSG0000028474132
PDE6B / P35913 / phosphodiesterase 6BENSG0000013325630
PDE6C / P51160 / phosphodiesterase 6CENSG0000009546429
PDE6A / P16499 / phosphodiesterase 6AENSG0000013291529
PDE10A / Q9Y233 / phosphodiesterase 10AENSG0000011254127
PDE2A / O00408 / phosphodiesterase 2AENSG0000018664225
PDE3B / Q13370 / phosphodiesterase 3BENSG0000015227015
PDE9A / O76083 / phosphodiesterase 9AENSG0000016019114
PDE3A / Q14432 / phosphodiesterase 3AENSG0000017257214


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0046068 cGMP metabolic process IEA
 biological_processGO:0046069 cGMP catabolic process IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IEA
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0060282 positive regulation of oocyte development IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030553 cGMP binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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