ENSG00000186642


Homo sapiens

Features
Gene ID: ENSG00000186642
  
Biological name :PDE2A
  
Synonyms : O00408 / PDE2A / phosphodiesterase 2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 72576141
Gene end: 72674591
  
Corresponding Affymetrix probe sets: 204134_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438559
Ensembl peptide - ENSP00000334910
Ensembl peptide - ENSP00000365633
Ensembl peptide - ENSP00000388997
Ensembl peptide - ENSP00000392457
Ensembl peptide - ENSP00000410310
Ensembl peptide - ENSP00000411657
Ensembl peptide - ENSP00000438008
Ensembl peptide - ENSP00000438295
Ensembl peptide - ENSP00000438868
Ensembl peptide - ENSP00000439077
Ensembl peptide - ENSP00000439302
Ensembl peptide - ENSP00000439683
Ensembl peptide - ENSP00000440834
Ensembl peptide - ENSP00000441322
Ensembl peptide - ENSP00000442256
Ensembl peptide - ENSP00000442797
Ensembl peptide - ENSP00000443232
Ensembl peptide - ENSP00000443737
Ensembl peptide - ENSP00000445443
Ensembl peptide - ENSP00000445750
Ensembl peptide - ENSP00000446399
NCBI entrez gene - 5138     See in Manteia.
OMIM - 602658
RefSeq - XM_017017910
RefSeq - XM_005274040
RefSeq - NM_001143839
RefSeq - NM_001243784
RefSeq - NM_002599
RefSeq - NM_001146209
RefSeq - XM_011545096
RefSeq Peptide - NP_001137311
RefSeq Peptide - NP_001139681
RefSeq Peptide - NP_001230713
RefSeq Peptide - NP_002590
swissprot - H0YG13
swissprot - H0YGL2
swissprot - H7C009
swissprot - F5H3Z7
swissprot - F5GXX2
swissprot - F5H130
swissprot - F5H143
swissprot - F5H1D7
swissprot - C9JPD5
swissprot - E9PEF1
swissprot - F5H2R8
swissprot - F5H2V7
swissprot - F5H2Z0
swissprot - O00408
swissprot - F5H5P8
swissprot - H0YFL1
Ensembl - ENSG00000186642
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079080.1ENSDARG00000079064Danio rerio
 Gm45837ENSMUSG00000030653Mus musculus
 Pde2aENSMUSG00000110195Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE11A / Q9HCR9 / phosphodiesterase 11AENSG0000012865526
PDE6B / P35913 / phosphodiesterase 6BENSG0000013325624
PDE10A / Q9Y233 / phosphodiesterase 10AENSG0000011254124
PDE5A / O76074 / phosphodiesterase 5AENSG0000013873523
PDE6A / P16499 / phosphodiesterase 6AENSG0000013291522
PDE11A / phosphodiesterase 11AENSG0000028474122
PDE6C / P51160 / phosphodiesterase 6CENSG0000009546421
PDE3B / Q13370 / phosphodiesterase 3BENSG0000015227015
PDE3A / Q14432 / phosphodiesterase 3AENSG0000017257214
PDE9A / O76083 / phosphodiesterase 9AENSG0000016019113


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006198 cAMP catabolic process IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0019933 cAMP-mediated signaling IMP
 biological_processGO:0019934 cGMP-mediated signaling IMP
 biological_processGO:0033159 negative regulation of protein import into nucleus, translocation IDA
 biological_processGO:0035690 cellular response to drug IMP
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IDA
 biological_processGO:0043116 negative regulation of vascular permeability IMP
 biological_processGO:0043117 positive regulation of vascular permeability IMP
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IDA
 biological_processGO:0046069 cGMP catabolic process IDA
 biological_processGO:0050729 positive regulation of inflammatory response ISS
 biological_processGO:0061028 establishment of endothelial barrier ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071260 cellular response to mechanical stimulus ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071321 cellular response to cGMP IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 biological_processGO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity TAS
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0008144 drug binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IMP
 molecular_functionGO:0030553 cGMP binding IMP
 molecular_functionGO:0030911 TPR domain binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity TAS


Pathways (from Reactome)
Pathway description
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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