ENSG00000152270


Homo sapiens

Features
Gene ID: ENSG00000152270
  
Biological name :PDE3B
  
Synonyms : PDE3B / phosphodiesterase 3B / Q13370
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.2
Gene start: 14643723
Gene end: 14872044
  
Corresponding Affymetrix probe sets: 208591_s_at (Human Genome U133 Plus 2.0 Array)   214582_at (Human Genome U133 Plus 2.0 Array)   222317_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282096
Ensembl peptide - ENSP00000388644
NCBI entrez gene - 5140     See in Manteia.
OMIM - 602047
RefSeq - XM_017017912
RefSeq - NM_000922
RefSeq - XM_006718249
RefSeq - XM_017017911
RefSeq Peptide - NP_000913
swissprot - Q13370
Ensembl - ENSG00000152270
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDE3BENSDARG00000062190Danio rerio
 PDE3BENSGALG00000006035Gallus gallus
 Pde3bENSMUSG00000030671Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE3A / Q14432 / phosphodiesterase 3AENSG0000017257244
PDE6C / P51160 / phosphodiesterase 6CENSG0000009546413
PDE2A / O00408 / phosphodiesterase 2AENSG0000018664213
PDE6B / P35913 / phosphodiesterase 6BENSG0000013325613
PDE11A / Q9HCR9 / phosphodiesterase 11AENSG0000012865512
PDE5A / O76074 / phosphodiesterase 5AENSG0000013873512
PDE6A / P16499 / phosphodiesterase 6AENSG0000013291512
PDE9A / O76083 / phosphodiesterase 9AENSG0000016019111
PDE11A / phosphodiesterase 11AENSG0000028474110
PDE10A / Q9Y233 / phosphodiesterase 10AENSG0000011254110


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006198 cAMP catabolic process IEP
 biological_processGO:0007162 negative regulation of cell adhesion IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IC
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling TAS
 biological_processGO:0050995 negative regulation of lipid catabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity EXP
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043422 protein kinase B binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity TAS


Pathways (from Reactome)
Pathway description
PDE3B signalling
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / reaction






 

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