ENSMUSG00000030671


Mus musculus

Features
Gene ID: ENSMUSG00000030671
  
Biological name :Pde3b
  
Synonyms : Pde3b / phosphodiesterase 3B
  
Possible biological names infered from orthology : Q13370
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 114415281
Gene end: 114539251
  
Corresponding Affymetrix probe sets: 10556528 (MoGene1.0st)   1433694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032909
NCBI entrez gene - 18576     See in Manteia.
MGI - MGI:1333863
RefSeq - NM_011055
RefSeq - XM_006507438
RefSeq Peptide - NP_035185
swissprot - E9QLQ3
Ensembl - ENSMUSG00000030671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDE3BENSDARG00000062190Danio rerio
 PDE3BENSGALG00000006035Gallus gallus
 PDE3BENSG00000152270Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174143
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499213
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457513
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949112
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019512
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527012
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065312
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111911
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396511
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386810


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PDE3B signalling
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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