ENSMUSG00000110195


Mus musculus

Features
Gene ID: ENSMUSG00000110195
  
Biological name :Pde2a
  
Synonyms : Pde2a / phosphodiesterase 2A, cGMP-stimulated
  
Possible biological names infered from orthology : O00408 / phosphodiesterase 2A
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 101421691
Gene end: 101512827
  
Corresponding Affymetrix probe sets: 10555510 (MoGene1.0st)   1447707_s_at (Mouse Genome 430 2.0 Array)   1452202_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147847
Ensembl peptide - ENSMUSP00000147553
Ensembl peptide - ENSMUSP00000147884
Ensembl peptide - ENSMUSP00000148212
Ensembl peptide - ENSMUSP00000127521
Ensembl peptide - ENSMUSP00000131553
NCBI entrez gene - 207728     See in Manteia.
MGI - MGI:2446107
RefSeq - XM_017322074
RefSeq - NM_001008548
RefSeq - NM_001143848
RefSeq - NM_001143849
RefSeq - NM_001243758
RefSeq - XM_006507523
RefSeq - XM_006507524
RefSeq - XM_006507528
RefSeq - XM_006507529
RefSeq - XM_017322073
RefSeq Peptide - NP_001230687
RefSeq Peptide - NP_001008548
RefSeq Peptide - NP_001137320
RefSeq Peptide - NP_001137321
swissprot - A0A1B0GRJ9
swissprot - Q5PR72
swissprot - A0A1B0GSC8
swissprot - Q3TXZ6
swissprot - A0A1B0GT58
Ensembl - ENSMUSG00000110195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079080.1ENSDARG00000079064Danio rerio
 PDE2AENSG00000186642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065395
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527025
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949124
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396523
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386823
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457522
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499221
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174114
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067114
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111913


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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