ENSMUSG00000023868


Mus musculus

Features
Gene ID: ENSMUSG00000023868
  
Biological name :Pde10a
  
Synonyms : Pde10a / phosphodiesterase 10A / Q8CA95
  
Possible biological names infered from orthology : Q9Y233
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 8525372
Gene end: 8986648
  
Corresponding Affymetrix probe sets: 10441680 (MoGene1.0st)   1419389_at (Mouse Genome 430 2.0 Array)   1419390_at (Mouse Genome 430 2.0 Array)   1432490_a_at (Mouse Genome 430 2.0 Array)   1439618_at (Mouse Genome 430 2.0 Array)   1458499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138135
Ensembl peptide - ENSMUSP00000111389
Ensembl peptide - ENSMUSP00000123216
Ensembl peptide - ENSMUSP00000024647
Ensembl peptide - ENSMUSP00000086485
Ensembl peptide - ENSMUSP00000111373
Ensembl peptide - ENSMUSP00000111380
Ensembl peptide - ENSMUSP00000111385
Ensembl peptide - ENSMUSP00000111387
NCBI entrez gene - 23984     See in Manteia.
MGI - MGI:1345143
RefSeq - XM_017317461
RefSeq - XM_006523316
RefSeq - XM_006523318
RefSeq - XM_006523319
RefSeq - XM_006523320
RefSeq - XM_006523321
RefSeq - XM_006523322
RefSeq - XM_006523323
RefSeq - XM_017317460
RefSeq - NM_001290707
RefSeq - NM_001347321
RefSeq - NM_011866
RefSeq Peptide - NP_001277636
RefSeq Peptide - NP_001334250
RefSeq Peptide - NP_035996
swissprot - S4R197
swissprot - F8WHK3
swissprot - D3YZR4
swissprot - F2Z3Z4
swissprot - Q8CA95
Ensembl - ENSMUSG00000023868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde10aENSDARG00000003449Danio rerio
 PDE10AENSGALG00000011537Gallus gallus
 PDE10AENSG00000112541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396530
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065328
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019528
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527028
Pde6c / Q91ZQ1 / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / phosphodiesterase 6C*ENSMUSG0000002499226
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949125
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457525
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067114
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174114
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111913


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010738 regulation of protein kinase A signaling IMP
 biological_processGO:0043949 regulation of cAMP-mediated signaling IMP
 biological_processGO:0046069 cGMP catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding ISO
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtbptm1Glo/Mtbp+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001462 abnormal avoidance learning behavior "defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0012317 impaired conditioning behavior "impaired ability to change behavior in response to a reward or punishment each time an action is performed" [http://dictionary.reference.com/browse/conditioning]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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