ENSMUSG00000024992


Mus musculus

Features
Gene ID: ENSMUSG00000024992
  
Biological name :Pde6c
  
Synonyms : Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / Pde6c / Q91ZQ1
  
Possible biological names infered from orthology : P51160 / phosphodiesterase 6C
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 38132781
Gene end: 38183958
  
Corresponding Affymetrix probe sets: 10462887 (MoGene1.0st)   1450830_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025956
Ensembl peptide - ENSMUSP00000107948
NCBI entrez gene - 110855     See in Manteia.
MGI - MGI:105956
RefSeq - NM_001170959
RefSeq - NM_033614
RefSeq Peptide - NP_001164430
RefSeq Peptide - NP_291092
swissprot - Q91ZQ1
Ensembl - ENSMUSG00000024992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde6cENSDARG00000100397Danio rerio
 PDE6CENSGALG00000006626Gallus gallus
 PDE6CENSG00000095464Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde6b / P23440 / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide / P35913* / phosphodiesterase 6B*ENSMUSG0000002949164
Pde6a / phosphodiesterase 6A / P16499*ENSMUSG0000002457562
P0C1Q2 / Pde11a / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A / Q9HCR9* / phosphodiesterase 11A*ENSMUSG0000007527030
Pde5a / Q8CG03 / cGMP-specific 3,5-cyclic phosphodiesterase / O76074* / phosphodiesterase 5A*ENSMUSG0000005396529
Pde10a / Q8CA95 / phosphodiesterase 10A / Q9Y233*ENSMUSG0000002386824
Pde2a / phosphodiesterase 2A, cGMP-stimulated / O00408* / phosphodiesterase 2A*ENSMUSG0000011019523
Gm45837 / cGMP-dependent 3,5-cyclic phosphodiesterase isoform PDE2A1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSMUSG0000003065323
Pde3a / Q9Z0X4 / phosphodiesterase 3A, cGMP inhibited / Q14432* / phosphodiesterase 3A*ENSMUSG0000004174119
Pde3b / phosphodiesterase 3B / Q13370*ENSMUSG0000003067116
Pde9a / O70628 / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A / O76083* / phosphodiesterase 9A*ENSMUSG0000004111914


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007603 phototransduction, visible light IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050953 sensory perception of light stimulus IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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