ENSDARG00000011671


Danio rerio

Features
Gene ID: ENSDARG00000011671
  
Biological name :pde6b
  
Synonyms : pde6b / phosphodiesterase 6B, cGMP-specific, rod, beta
  
Possible biological names infered from orthology : P23440 / P35913 / phosphodiesterase 6B / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 20356458
Gene end: 20376607
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000123023
NCBI entrez gene - 559332     See in Manteia.
RefSeq - XM_679910
swissprot - E7F5I9
ZFIN ID - ZDB-GENE-090421-2
Ensembl - ENSDARG00000011671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDE6BENSGALG00000015373Gallus gallus
 PDE6BENSG00000133256Homo sapiens
 Pde6bENSMUSG00000029491Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pde6a / phosphodiesterase 6A, cGMP-specific, rod, alpha / P16499* / phosphodiesterase 6A*ENSDARG0000000038073
pde6c / phosphodiesterase 6C, cGMP-specific, cone, alpha prime / P51160* / Q91ZQ1* / phosphodiesterase 6C* / Cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha *ENSDARG0000010039762
pde11a / phosphodiesterase 11a / P0C1Q2* / Q9HCR9* / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A *ENSDARG0000006373230
pde11al / phosphodiesterase 11a, likeENSDARG0000000615130
pde5ab / phosphodiesterase 5A, cGMP-specific, b / PDE5A* / Q8CG03* / O76074* / phosphodiesterase 5A* / cGMP-specific 3,5-cyclic phosphodiesterase *ENSDARG0000005191528
pde10a / phosphodiesterase 10A / Q8CA95* / Q9Y233*ENSDARG0000000344923
pde3a / phosphodiesterase 3A, cGMP-inhibited / Q14432* / Q9Z0X4* / phosphodiesterase 3A*ENSDARG0000000422718
PDE3B / si:ch211-79e4.4 / Q13370* / phosphodiesterase 3B*ENSDARG0000006219016
FQ378016.1 / PDE9A* / O76083* / phosphodiesterase 9A*ENSDARG0000010893915
pde9al / phosphodiesterase 9A like / PDE9A* / O76083* / phosphodiesterase 9A*ENSDARG0000007665015
pde9a / phosphodiesterase 9A / O70628* / O76083* / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A *ENSDARG0000006028014
si:dkey-219c10.4ENSDARG0000007592911
pde5aa / phosphodiesterase 5A, cGMP-specific, aENSDARG000000568067
CABZ01079080.1 / PDE2A* / O00408* / phosphodiesterase 2A*ENSDARG000000790644


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009127 photoreceptor cell photoreceptor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000000380 pde6a / phosphodiesterase 6A, cGMP-specific, rod, alpha / P16499* / phosphodiesterase 6A*  / complex
 ENSDARG00000042529 gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...  / complex
 ENSDARG00000044199 gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...  / complex
 ENSDARG00000101984 pde6gb / phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b / PDE6G* / P18545* / phosphodiesterase 6G*  / complex






 

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