ENSDARG00000044199


Danio rerio

Features
Gene ID: ENSDARG00000044199
  
Biological name :gnat1
  
Synonyms : gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
  
Possible biological names infered from orthology : G protein subunit alpha transducin 1 / guanine nucleotide binding protein, alpha transducing 1 / P11488 / P20612
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 42918933
Gene end: 42930302
  
Corresponding Affymetrix probe sets: Dr.9899.1.S1_at (Zebrafish Array)   Dr.9899.1.S2_at (Zebrafish Array)   NM_131868_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000064895
NCBI entrez gene - 140428     See in Manteia.
RefSeq - NM_131868
RefSeq Peptide - NP_571943
swissprot - Q90WX6
ZFIN ID - ZDB-GENE-011128-11
Ensembl - ENSDARG00000044199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAT1ENSGALG00000028697Gallus gallus
 GNAT1ENSG00000114349Homo sapiens
 Gnat1ENSMUSG00000034837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...ENSDARG0000004252977
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSDARG0000002164767
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...ENSDARG0000003064466
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001729465
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide aENSDARG0000004476065
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001817465
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000003605862
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000001667662
GNAZ / G protein subunit alpha z / P19086*ENSDARG0000009984454
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*ENSDARG0000001148751
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)ENSDARG0000005332650
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)ENSDARG0000001000250
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*ENSDARG0000002501349
gna14 / guanine nucleotide binding protein (G protein), alpha 14ENSDARG0000003517845
gnav1 / guanine nucleotide binding protein (G protein) alpha v1ENSDARG0000004300645
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...ENSDARG0000001636443
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...ENSDARG0000005665441
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*ENSDARG0000003792440
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*ENSDARG0000002582639
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*ENSDARG0000007376539


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0009416 response to light stimulus ISS
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000000380 pde6a / phosphodiesterase 6A, cGMP-specific, rod, alpha / P16499* / phosphodiesterase 6A*  / complex
 ENSDARG00000035798 gngt1 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / GNG11* / Q61012* / P61952* / P61953* / P63211* / G protein subunit gamma 11* / G protein s...  / complex
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / reaction / complex
 ENSDARG00000044861 Q8AYN0 / opn1lw2 / opsin 1 (cone pigments), long-wave-sensitive, 2 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex
 ENSDARG00000044862 Q9W6A7 / opn1lw1 / opsin 1 (cone pigments), long-wave-sensitive, 1 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / reaction / complex
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / reaction / complex
 ENSDARG00000052966 nmt1a / N-myristoyltransferase 1a / NMT1* / P30419* / O70310* / N-myristoyltransferase 1* / Glycylpeptide N-tetradecanoyltransferase 1 *  / reaction
 ENSDARG00000011671 pde6b / phosphodiesterase 6B, cGMP-specific, rod, beta / P35913* / P23440* / phosphodiesterase 6B* / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide*  / complex
 ENSDARG00000069261 metap2a / methionyl aminopeptidase 2a / P50579* / METAP2* / O08663* / methionyl aminopeptidase 2* / methionine aminopeptidase 2*  / reaction
 ENSDARG00000033440 metap1 / methionyl aminopeptidase 1 / P53582* / Q8BP48* / Methionine aminopeptidase 1 *  / reaction
 ENSDARG00000021808 nmt2 / N-myristoyltransferase 2 / O60551* / O70311* / Glycylpeptide N-tetradecanoyltransferase 2 *  / reaction
 ENSDARG00000101984 pde6gb / phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b / PDE6G* / P18545* / phosphodiesterase 6G*  / complex
 ENSDARG00000102571 metap2b / methionyl aminopeptidase 2b / P50579* / METAP2* / O08663* / methionyl aminopeptidase 2* / methionine aminopeptidase 2*  / reaction






 

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