ENSDARG00000102571


Danio rerio

Features
Gene ID: ENSDARG00000102571
  
Biological name :metap2b
  
Synonyms : metap2b / methionyl aminopeptidase 2b
  
Possible biological names infered from orthology : METAP2 / methionine aminopeptidase 2 / methionyl aminopeptidase 2 / O08663 / P50579
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 3231812
Gene end: 3247343
  
Corresponding Affymetrix probe sets: Dr.13563.1.S1_at (Zebrafish Array)   Dr.16519.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000139312
swissprot - A0A0R4IUB7
ZFIN ID - ZDB-GENE-030131-2172
Ensembl - ENSDARG00000102571
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 METAP2ENSGALG00000011377Gallus gallus
 METAP2ENSG00000111142Homo sapiens
 Metap2ENSMUSG00000036112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
metap2a / methionyl aminopeptidase 2a / P50579* / METAP2* / O08663* / methionyl aminopeptidase 2* / methionine aminopeptidase 2*ENSDARG0000006926177
pa2g4b / proliferation-associated 2G4, b / PA2G4* / Q9UQ80* / P50580* / AC034102.2* / proliferation-associated 2G4* / Proliferation-associated protein 2G4 *ENSDARG0000007065715
pa2g4a / proliferation-associated 2G4, a / PA2G4* / Q9UQ80* / P50580* / AC034102.2* / proliferation-associated 2G4* / Proliferation-associated protein 2G4 *ENSDARG0000003957815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000994  Peptidase M24
 IPR001714  Peptidase M24, methionine aminopeptidase
 IPR002468  Peptidase M24A, methionine aminopeptidase, subfamily 2
 IPR011991  ArsR-like helix-turn-helix domain
 IPR018349  Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0070084 protein initiator methionine removal IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008235 metalloexopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044199 gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...  / reaction






 

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