ENSG00000111142


Homo sapiens

Features
Gene ID: ENSG00000111142
  
Biological name :METAP2
  
Synonyms : METAP2 / methionyl aminopeptidase 2 / P50579
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q22
Gene start: 95473520
Gene end: 95515839
  
Corresponding Affymetrix probe sets: 209861_s_at (Human Genome U133 Plus 2.0 Array)   213899_at (Human Genome U133 Plus 2.0 Array)   227993_at (Human Genome U133 Plus 2.0 Array)   244185_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449004
Ensembl peptide - ENSP00000448614
Ensembl peptide - ENSP00000450063
Ensembl peptide - ENSP00000261220
Ensembl peptide - ENSP00000325312
Ensembl peptide - ENSP00000446052
Ensembl peptide - ENSP00000447661
Ensembl peptide - ENSP00000448169
Ensembl peptide - ENSP00000448370
NCBI entrez gene - 10988     See in Manteia.
OMIM - 601870
RefSeq - XM_005268583
RefSeq - NM_001317182
RefSeq - NM_001317183
RefSeq - NM_001330246
RefSeq - NM_006838
RefSeq Peptide - NP_001317175
RefSeq Peptide - NP_006829
RefSeq Peptide - NP_001304111
RefSeq Peptide - NP_001304112
swissprot - F8VQZ7
swissprot - F8VRR3
swissprot - F8VSC4
swissprot - F8VZX9
swissprot - F8VY03
swissprot - G3V1U3
swissprot - P50579
swissprot - A0A140VJE3
Ensembl - ENSG00000111142
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 metap2aENSDARG00000069261Danio rerio
 metap2bENSDARG00000102571Danio rerio
 METAP2ENSGALG00000011377Gallus gallus
 Metap2ENSMUSG00000036112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PA2G4 / Q9UQ80 / proliferation-associated 2G4ENSG0000017051515
AC034102.2ENSG000002574118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000994  Peptidase M24
 IPR001714  Peptidase M24, methionine aminopeptidase
 IPR002468  Peptidase M24A, methionine aminopeptidase, subfamily 2
 IPR018349  Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
 IPR036005  Creatinase/aminopeptidase-like
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0018206 peptidyl-methionine modification IDA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0031365 N-terminal protein amino acid modification IDA
 biological_processGO:0070084 protein initiator methionine removal IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008235 metalloexopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114349 GNAT1 / P11488 / G protein subunit alpha transducin 1  / reaction






 

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