ENSMUSG00000036112


Mus musculus

Features
Gene ID: ENSMUSG00000036112
  
Biological name :Metap2
  
Synonyms : Metap2 / methionine aminopeptidase 2 / O08663
  
Possible biological names infered from orthology : methionyl aminopeptidase 2 / P50579
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 93858489
Gene end: 93897093
  
Corresponding Affymetrix probe sets: 10371987 (MoGene1.0st)   1423610_at (Mouse Genome 430 2.0 Array)   1434120_a_at (Mouse Genome 430 2.0 Array)   1436531_at (Mouse Genome 430 2.0 Array)   1451048_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138083
Ensembl peptide - ENSMUSP00000048285
Ensembl peptide - ENSMUSP00000137652
Ensembl peptide - ENSMUSP00000137681
Ensembl peptide - ENSMUSP00000137904
Ensembl peptide - ENSMUSP00000137911
Ensembl peptide - ENSMUSP00000138006
Ensembl peptide - ENSMUSP00000138050
NCBI entrez gene - 56307     See in Manteia.
MGI - MGI:1929701
RefSeq - XM_017314032
RefSeq - NM_019648
RefSeq - XM_006513896
RefSeq - XM_006513897
RefSeq Peptide - NP_062622
swissprot - O08663
swissprot - Q3TMN1
swissprot - Q3UI33
swissprot - Q58E65
swissprot - M0QWM9
swissprot - M0QWX0
swissprot - M0QW48
swissprot - M0QW69
Ensembl - ENSMUSG00000036112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 metap2aENSDARG00000069261Danio rerio
 metap2bENSDARG00000102571Danio rerio
 METAP2ENSGALG00000011377Gallus gallus
 METAP2ENSG00000111142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pa2g4 / P50580 / Proliferation-associated protein 2G4 / Q9UQ80* / AC034102.2* / proliferation-associated 2G4*ENSMUSG0000002536415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000994  Peptidase M24
 IPR001714  Peptidase M24, methionine aminopeptidase
 IPR002468  Peptidase M24A, methionine aminopeptidase, subfamily 2
 IPR018349  Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
 IPR036005  Creatinase/aminopeptidase-like
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing ISS
 biological_processGO:0018206 peptidyl-methionine modification ISO
 biological_processGO:0031365 N-terminal protein amino acid modification ISO
 biological_processGO:0070084 protein initiator methionine removal IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008235 metalloexopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Metap2tm1.2Ccr/Metap2tm1.2Ccr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Metap2tm1.2Ccr/Metap2tm1.2Ccr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Metap2tm1.2Ccr/Metap2tm1.2Ccr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr