ENSMUSG00000025364


Mus musculus

Features
Gene ID: ENSMUSG00000025364
  
Biological name :Pa2g4
  
Synonyms : P50580 / Pa2g4 / Proliferation-associated protein 2G4
  
Possible biological names infered from orthology : AC034102.2 / proliferation-associated 2G4 / Q9UQ80
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128557766
Gene end: 128565987
  
Corresponding Affymetrix probe sets: 10373454 (MoGene1.0st)   1420142_s_at (Mouse Genome 430 2.0 Array)   1423060_at (Mouse Genome 430 2.0 Array)   1435372_a_at (Mouse Genome 430 2.0 Array)   1450854_at (Mouse Genome 430 2.0 Array)   1460265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026425
Ensembl peptide - ENSMUSP00000114434
NCBI entrez gene - 18813     See in Manteia.
MGI - MGI:894684
RefSeq - NM_011119
RefSeq Peptide - NP_035249
swissprot - P50580
swissprot - Q3TGU7
Ensembl - ENSMUSG00000025364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pa2g4aENSDARG00000039578Danio rerio
 pa2g4bENSDARG00000070657Danio rerio
 ENSGALG00000034218Gallus gallus
 AC034102.2ENSG00000257411Homo sapiens
 PA2G4ENSG00000170515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Metap2 / O08663 / methionine aminopeptidase 2 / P50579* / methionyl aminopeptidase 2*ENSMUSG0000003611219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000994  Peptidase M24
 IPR004545  PA2G4 family
 IPR018349  Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
 IPR036005  Creatinase/aminopeptidase-like
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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