ENSDARG00000025013


Danio rerio

Features
Gene ID: ENSDARG00000025013
  
Biological name :gna14a
  
Synonyms : gna14a / guanine nucleotide binding protein (G protein), alpha 14a
  
Possible biological names infered from orthology : GNA14 / G protein subunit alpha 14 / guanine nucleotide binding protein, alpha 14 / O95837 / P30677
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 51958968
Gene end: 51986997
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000122726
Ensembl peptide - ENSDARP00000149285
NCBI entrez gene - 556160     See in Manteia.
swissprot - B0S554
swissprot - E9QIX5
ZFIN ID - ZDB-GENE-081105-76
Ensembl - ENSDARG00000025013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNA14ENSGALG00000015176Gallus gallus
 GNA14ENSG00000156049Homo sapiens
 Gna14ENSMUSG00000024697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)ENSDARG0000005332671
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)ENSDARG0000001000270
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*ENSDARG0000001148770
gna14 / guanine nucleotide binding protein (G protein), alpha 14ENSDARG0000003517866
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...ENSDARG0000001636454
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...ENSDARG0000005665451
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000001667648
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001729447
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide aENSDARG0000004476047
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...ENSDARG0000004419947
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000003605846
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...ENSDARG0000004252945
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*ENSDARG0000003792445
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSDARG0000002164745
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...ENSDARG0000003064445
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001817445
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*ENSDARG0000007376544
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*ENSDARG0000002582643
GNAZ / G protein subunit alpha z / P19086*ENSDARG0000009984443
gnav1 / guanine nucleotide binding protein (G protein) alpha v1ENSDARG0000004300642


Protein motifs (from Interpro)
Interpro ID Name
 IPR000654  G-protein alpha subunit, group Q
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000068246 plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*  / reaction / complex
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / reaction / complex
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / reaction / complex
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / reaction / complex
 ENSDARG00000090381 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction / complex
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSDARG00000014465 arhgef25b / Rho guanine nucleotide exchange factor (GEF) 25b / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 2...  / reaction / complex
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / reaction / complex
 ENSDARG00000100606 BX539336.1 / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25*  / reaction / complex
 ENSDARG00000100786 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction / complex
 ENSDARG00000105281 p2ry1 / purinergic receptor P2Y1 / P47900* / P49650* / purinergic receptor P2Y, G-protein coupled 1*  / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction






 

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