Manteia

ENSG00000156049

Homo sapiens

Features

Gene ID:	ENSG00000156049

Biological name :	GNA14

Synonyms :	GNA14 / G protein subunit alpha 14 / O95837

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	9
Strand:	-1
Band:	q21.2
Gene start:	77423079
Gene end:	77648307

Corresponding Affymetrix probe sets:	220108_at (Human Genome U133 Plus 2.0 Array) 243580_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000365807 NCBI entrez gene - 9630 See in Manteia. OMIM - 604397 RefSeq - XM_017015341 RefSeq - NM_004297 RefSeq - XM_011519224 RefSeq Peptide - NP_004288 swissprot - O95837 Ensembl - ENSG00000156049

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gna14a	ENSDARG00000025013	Danio rerio
GNA14	ENSGALG00000015176	Gallus gallus
Gna14	ENSMUSG00000024697	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
GNA11 / P29992 / G protein subunit alpha 11	ENSG00000088256	82
GNAQ / P50148 / G protein subunit alpha q	ENSG00000156052	81
GNA15 / P30679 / G protein subunit alpha 15	ENSG00000060558	55
GNAO1 / P09471 / G protein subunit alpha o1	ENSG00000087258	52
GNAI1 / P63096 / G protein subunit alpha i1	ENSG00000127955	52
GNAI3 / P08754 / G protein subunit alpha i3	ENSG00000065135	51
GNAI2 / P04899 / G protein subunit alpha i2	ENSG00000114353	50
GNAT1 / P11488 / G protein subunit alpha transducin 1	ENSG00000114349	50
GNAT2 / P19087 / G protein subunit alpha transducin 2	ENSG00000134183	49
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3	ENSG00000214415	49
GNAZ / P19086 / G protein subunit alpha z	ENSG00000128266	47
GNA13 / Q14344 / G protein subunit alpha 13	ENSG00000120063	46
GNA12 / Q03113 / G protein subunit alpha 12	ENSG00000146535	41

Protein motifs (from Interpro)

Interpro ID	Name
IPR000654	G-protein alpha subunit, group Q
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
IPR011025	G protein alpha subunit, helical insertion
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IBA
cellular_component	GO:0005834	heterotrimeric G-protein complex	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IBA
molecular_function	GO:0003924	GTPase activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	NAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0019001	guanyl nucleotide binding	IEA
molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Acetylcholine regulates insulin secretion

G alpha (q) signalling events

ADP signalling through P2Y purinoceptor 1

Thromboxane signalling through TP receptor

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion

Thrombin signalling through proteinase activated receptors (PARs)

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000127533	F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3	/ complex / reaction
ENSG00000137841	PLCB2 / Q00722 / phospholipase C beta 2	/ reaction / complex
ENSG00000101333	PLCB4 / Q15147 / phospholipase C beta 4	/ reaction / complex
ENSG00000149782	PLCB3 / Q01970 / phospholipase C beta 3	/ reaction / complex
ENSG00000164220	F2RL2 / O00254 / coagulation factor II thrombin receptor like 2	/ complex / reaction
ENSG00000173020	GRK2 / P25098 / G protein-coupled receptor kinase 2	/ reaction / complex
ENSG00000169860	P2RY1 / P47900 / purinergic receptor P2Y1	/ complex / reaction
ENSG00000181104	F2R / P25116 / coagulation factor II thrombin receptor	/ complex / reaction
ENSG00000038382	TRIO / O75962 / trio Rho guanine nucleotide exchange factor	/ complex / reaction
ENSG00000240771	Q86VW2 / ARHGEF25 / Rho guanine nucleotide exchange factor 25	/ complex / reaction
ENSG00000160145	KALRN / O60229 / kalirin RhoGEF kinase	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ reaction / complex
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000198873	GRK5 / P34947 / G protein-coupled receptor kinase 5	/ reaction / complex
ENSG00000182621	PLCB1 / Q9NQ66 / phospholipase C beta 1	/ reaction / complex
ENSG00000078369	GNB1 / P62873 / G protein subunit beta 1	/ complex / reaction
ENSG00000186469	GNG2 / P59768 / G protein subunit gamma 2	/ complex / reaction
ENSG00000006638	P21731 / TBXA2R / thromboxane A2 receptor	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr