ENSG00000137841


Homo sapiens

Features
Gene ID: ENSG00000137841
  
Biological name :PLCB2
  
Synonyms : phospholipase C beta 2 / PLCB2 / Q00722
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 40278176
Gene end: 40307935
  
Corresponding Affymetrix probe sets: 204046_at (Human Genome U133 Plus 2.0 Array)   210388_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454025
Ensembl peptide - ENSP00000452916
Ensembl peptide - ENSP00000453975
Ensembl peptide - ENSP00000260402
Ensembl peptide - ENSP00000411991
Ensembl peptide - ENSP00000444652
NCBI entrez gene - 5330     See in Manteia.
OMIM - 604114
RefSeq - XM_017022319
RefSeq - NM_001284299
RefSeq - NM_004573
RefSeq - XM_011521674
RefSeq - XM_017022314
RefSeq - XM_017022315
RefSeq - XM_017022316
RefSeq - XM_017022317
RefSeq - XM_017022318
RefSeq - NM_001284297
RefSeq - NM_001284298
RefSeq Peptide - NP_004564
RefSeq Peptide - NP_001271226
RefSeq Peptide - NP_001271227
RefSeq Peptide - NP_001271228
swissprot - H0YKR9
swissprot - Q00722
swissprot - Q9BVT6
swissprot - H0YNI4
Ensembl - ENSG00000137841
  
Related genetic diseases (OMIM): 604114 - Platelet PLC beta-2 deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB2ENSDARG00000090381Danio rerio
 PLCB2ENSGALG00000042105Gallus gallus
 Plcb2ENSMUSG00000040061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262147
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978245
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133334
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482223
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480523
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952723
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589621
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171420
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555620
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709119
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028403  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007202 activation of phospholipase C activity TAS
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0050913 sensory perception of bitter taste IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Acetylcholine regulates insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / reaction / complex
 ENSG00000101333 PLCB4 / Q15147 / phospholipase C beta 4  / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000137841 PLCB2 / Q00722 / phospholipase C beta 2  / reaction
 ENSG00000149782 PLCB3 / Q01970 / phospholipase C beta 3  / reaction
 ENSG00000182621 PLCB1 / Q9NQ66 / phospholipase C beta 1  / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction






 

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