ENSG00000114805


Homo sapiens

Features
Gene ID: ENSG00000114805
  
Biological name :PLCH1
  
Synonyms : phospholipase C eta 1 / PLCH1 / Q4KWH8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.31
Gene start: 155375580
Gene end: 155745067
  
Corresponding Affymetrix probe sets: 214745_at (Human Genome U133 Plus 2.0 Array)   216633_s_at (Human Genome U133 Plus 2.0 Array)   216634_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402759
Ensembl peptide - ENSP00000335469
Ensembl peptide - ENSP00000345988
Ensembl peptide - ENSP00000417502
Ensembl peptide - ENSP00000419100
NCBI entrez gene - 23007     See in Manteia.
OMIM - 612835
RefSeq - XM_017005929
RefSeq - NM_001130960
RefSeq - NM_001130961
RefSeq - NM_001349250
RefSeq - NM_001349251
RefSeq - NM_001349252
RefSeq - NM_014996
RefSeq - XM_011512567
RefSeq - XM_017005923
RefSeq - XM_017005924
RefSeq - XM_017005925
RefSeq - XM_017005926
RefSeq - XM_017005927
RefSeq - XM_017005928
RefSeq - XM_005247238
RefSeq - XM_005247239
RefSeq - XM_011512560
RefSeq - XM_011512561
RefSeq - XM_011512562
RefSeq - XM_011512564
RefSeq - XM_011512565
RefSeq - XM_011512566
RefSeq Peptide - NP_001336181
RefSeq Peptide - NP_001336179
RefSeq Peptide - NP_001336180
RefSeq Peptide - NP_001124433
RefSeq Peptide - NP_055811
RefSeq Peptide - NP_001124432
swissprot - Q4KWH8
Ensembl - ENSG00000114805
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plch1ENSDARG00000079253Danio rerio
 PLCH1ENSGALG00000010312Gallus gallus
 Plch1ENSMUSG00000036834Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952742
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589620
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482219
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555618
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133317
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978217
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171416
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784116
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709116
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262116
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028392  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050429 calcium-dependent phospholipase C activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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