ENSG00000149527


Homo sapiens

Features
Gene ID: ENSG00000149527
  
Biological name :PLCH2
  
Synonyms : O75038 / phospholipase C eta 2 / PLCH2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.32
Gene start: 2425980
Gene end: 2505530
  
Corresponding Affymetrix probe sets: 206080_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000278878
Ensembl peptide - ENSP00000389803
Ensembl peptide - ENSP00000397289
Ensembl peptide - ENSP00000476436
Ensembl peptide - ENSP00000367747
NCBI entrez gene - 9651     See in Manteia.
OMIM - 612836
RefSeq - XM_017002874
RefSeq - NM_001303012
RefSeq - NM_001303013
RefSeq - NM_014638
RefSeq - XM_011542455
RefSeq - XM_011542456
RefSeq - XM_017002870
RefSeq - XM_017002871
RefSeq - XM_017002872
RefSeq - XM_017002873
RefSeq Peptide - NP_001289941
RefSeq Peptide - NP_001289942
RefSeq Peptide - NP_055453
swissprot - O75038
swissprot - V9GY64
swissprot - B9DI82
Ensembl - ENSG00000149527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plch2aENSDARG00000059960Danio rerio
 plch2bENSDARG00000056805Danio rerio
 PLCH2ENSGALG00000001207Gallus gallus
 Plch2ENSMUSG00000029055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480550
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589624
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482223
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555622
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709121
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262120
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171420
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133320
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978220
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784119
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028392  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
 IPR028393  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050429 calcium-dependent phospholipase C activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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