ENSG00000115896


Homo sapiens

Features
Gene ID: ENSG00000115896
  
Biological name :PLCL1
  
Synonyms : phospholipase C like 1 (inactive) / PLCL1 / Q15111
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.1
Gene start: 197804702
Gene end: 198572581
  
Corresponding Affymetrix probe sets: 205934_at (Human Genome U133 Plus 2.0 Array)   241859_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457588
Ensembl peptide - ENSP00000402861
Ensembl peptide - ENSP00000410488
Ensembl peptide - ENSP00000414138
NCBI entrez gene - 5334     See in Manteia.
OMIM - 600597
RefSeq - XM_017004340
RefSeq - NM_006226
RefSeq - XM_005246643
RefSeq - XM_005246644
RefSeq - XM_011511351
RefSeq - XM_017004339
RefSeq Peptide - NP_006217
swissprot - F8WAR2
swissprot - H3BUD4
swissprot - A0A0A0MT40
swissprot - Q15111
Ensembl - ENSG00000115896
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcl1ENSDARG00000067676Danio rerio
 PLCL1ENSGALG00000008113Gallus gallus
 Plcl1ENSMUSG00000038349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482264
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952731
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480531
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709126
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555625
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171424
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978224
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262124
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784123
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133323
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028382  Inactive phospholipase C-like protein 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0050811 GABA receptor binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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