ENSG00000115556


Homo sapiens

Features
Gene ID: ENSG00000115556
  
Biological name :PLCD4
  
Synonyms : phospholipase C delta 4 / PLCD4 / Q9BRC7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 218607765
Gene end: 218637184
  
Corresponding Affymetrix probe sets: 224505_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404481
Ensembl peptide - ENSP00000403935
Ensembl peptide - ENSP00000406040
Ensembl peptide - ENSP00000415725
Ensembl peptide - ENSP00000388631
Ensembl peptide - ENSP00000391850
Ensembl peptide - ENSP00000396185
Ensembl peptide - ENSP00000396942
NCBI entrez gene - 84812     See in Manteia.
OMIM - 605939
RefSeq - XM_017005119
RefSeq - XM_005246913
RefSeq - XM_011512012
RefSeq - XM_017005114
RefSeq - XM_017005115
RefSeq - XM_017005116
RefSeq - XM_017005117
RefSeq - XM_017005118
RefSeq - NM_032726
RefSeq Peptide - NP_116115
swissprot - F2Z3H8
swissprot - H7C237
swissprot - C9JEA7
swissprot - C9JAE4
swissprot - Q9BRC7
swissprot - H7C281
Ensembl - ENSG00000115556
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcd4aENSDARG00000057975Danio rerio
 plcd4bENSDARG00000040684Danio rerio
 PLCD4ENSGALG00000026687Gallus gallus
 Plcd4ENSMUSG00000026173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171448
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709147
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952741
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480539
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589637
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482237
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915136
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262133
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133333
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978232
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784131


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028387  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr