ENSG00000154822


Homo sapiens

Features
Gene ID: ENSG00000154822
  
Biological name :PLCL2
  
Synonyms : phospholipase C like 2 / PLCL2 / Q9UPR0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.3
Gene start: 16802651
Gene end: 17090594
  
Corresponding Affymetrix probe sets: 213309_at (Human Genome U133 Plus 2.0 Array)   216217_at (Human Genome U133 Plus 2.0 Array)   216218_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404433
Ensembl peptide - ENSP00000412836
Ensembl peptide - ENSP00000478458
NCBI entrez gene - 23228     See in Manteia.
OMIM - 614276
RefSeq - XM_017006025
RefSeq - NM_001144382
RefSeq - NM_015184
RefSeq - XM_006713073
RefSeq - XM_017006022
RefSeq - XM_017006023
RefSeq - XM_017006024
RefSeq Peptide - NP_001137854
RefSeq Peptide - NP_055999
swissprot - Q9UPR0
swissprot - H7C276
Ensembl - ENSG00000154822
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcl2ENSDARG00000098826Danio rerio
 PLCL2ENSGALG00000011248Gallus gallus
 Plcl2ENSMUSG00000038910Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589662
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480529
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952729
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555625
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709125
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978224
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784124
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262124
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171424
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133323
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028382  Inactive phospholipase C-like protein 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002322 B cell proliferation involved in immune response IEA
 biological_processGO:0002337 B-1a B cell differentiation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0050811 GABA receptor binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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